Fusobacterium nucleatum-induced imbalance in microbiome-derived butyric acid levels promotes the occurrence and development of colorectal cancer

Figure 4 Fusobacteriumnucleatum inhibits the formation of the short chain fatty acid butyric acid. A and B: Positive ion mode PLS-DA analysis diagram and negative ion mode PLS-DA analysis diagram show that there is a significant difference between the feces of mice treated with Fusobacterium nucleatum (F. nucleatum) and the control group (NC) in the PC1 direction (n = 6 for each group); C-F: The total amount of short-chain fatty acids (SCFAs), butyric acid, and isobutyric acid was significantly lower in the treatment group of F. nucleatum than the untreated group (n = 3 for each group). NFn: F. nucleatum treatment group. ^aP < 0.05.