Preoperative albumin-bilirubin score and liver resection percentage determine postoperative liver regeneration after partial hepatectomy

Table 3 Risk factors for delayed regeneration and failure for restoration of the original volume

	Delayed regeneration (total n = 153)				Volume restoration failure (total n = 191)
	Univariate OR (95%CI)	P value	Multivariate OR (95%CI)	P value	Univariate OR (95%CI)	P value	Multivariate OR (95%CI)	P value
Age > 75, yes	0.67 (0.27-1.68)	0.45	-	-	0.94 (0.46-1.94)	0.88	-	-
Gender, male, yes	1.14 (0.48-2.67)	0.77	-	-	0.76 (0.40-1.45)	0.41	-	-
BMI > 28 kg/m2, yes	0.22 (0.03-1.74)	0.15	-	-	0.44 (0.14-1.46)	0.18	-	-
Background, HCC	-	Ref.			-	Ref.
CCC & CHC	0.49 (0.13-1.82)	0.29	-	-	1.64 (0.73-3.65)	0.23	0.40 (0.15-1.11)	0.08
Colorectal liver metastasis	1.83 (0.73-4.56)	0.19	-	-	0.88 (0.34-1.90)	0.81	0.71 (0.22-2.26)	0.56
Others	1.10 (0.27-4.42)	0.90	-	-	2.39 (0.95-6.00)	0.07	0.28 (0.08-0.97)	0.44
HCV positive, yes	0.61 (0.26-1.47)	0.27	-	-	0.70 (0.37-1.34)	0.28	-	-
Diabetes mellitus, yes	0.64 (0.30-1.39)	0.26	-	-	0.55 (0.30-1.00)	0.05	0.69 (0.36-1.35)	0.28
Renal complication, yes	0.89 (0.18-4.48)	0.88	-	-	1.15 (0.37-3.56)	0.81	-	-
Heavy alcoholic, yes	0.86 (0.39-1.88)	0.71	-	-	0.84 (0.46-1.53)	0.56	-	-
Preoperative platelet count < 100 × 103/uL, yes	1.60 (0.28-9.11)	0.60	-	-	4.17 (0.82-21.21)	0.09	4.34 (0.81-23.40)	0.09
Preoperative ALBI score (per 1.0 up)	1.13 (0.46-2.81)	0.79	-	-	2.76 (1.27-5.97)	0.01	2.63 (1.15-6.04)	0.02
ICG 15 min rate (per 1.0 up)	1.00 (0.97-1.04)	0.99	-	-	1.00 (0.98-1.04)	0.58	-	-
Liver cirrhosis (F4), yes	1.94 (0.70-5.38)	0.20	-	-	1.22 (0.47-3.15)	0.69	-	-
Preoperative chemotherapy, yes	2.01 (0.80-5.03)	0.14	-	-	0.80 (0.34-1.87)	0.60	-	-
Re-hepatectomy, yes	1.67 (0.40-7.03)	0.49	-	-	0.74 (0.21-2.62)	0.64	-	-
Liver resection percentage (per 1.0% up)	1.03 (1.00-1.05)	0.04	1.03 (1.00-1.05)	0.04	1.03 (1.01-1.05)	0.008	1.02 (1.00-1.05)	0.04
Intraoperative blood loss > 1000 mL, yes	1.35 (0.58-3.15)	0.49	-	-	1.41 (0.69-2.86)	0.34	-	-
RBC transfusion, yes	0.55 (0.12-2.58)	0.58	-	-	1.04 (0.35-3.12)	0.95	-	-
Pringle time > 90 min, yes	1.82 (0.80-4.14)	0.16	-	-	0.91 (0.46-1.81)	0.78	-	-
Posthepatectomy liver failure grade B/C, yes	0.95 (0.24-3.60)	0.92	-	-	1.83 (0.61-5.50)	0.28	-	-
Postoperative complication CD grade ≥ 3, yes	0.54 (0.19-1.53)	0.24	-	-	1.97 (0.95-4.07)	0.07	1.80 (0.83-3.91)	0.14

OR: Odds ratio; BMI: Body mass index; HCC: Hepatocellular carcinoma; CCC: Cholangiocellular carcinoma; CHC: Combined hepatocellular carcinoma and cholangiocellular carcinoma; HCV: Hepatitis C virus; ALBI: Albumin-bilirubin; ICG: Indocyanine green; RBC: Red blood cell; CD: Clavien-Dindo.