Preoperative albumin-bilirubin score and liver resection percentage determine postoperative liver regeneration after partial hepatectomy

Table 2 Risk factors for low regeneration at 3-months and 12-months posthepatectomy

	3-months (n = 187)				12-months (n = 192)
	Univariate OR (95%CI)	P value	Multivariate OR (95%CI)	P value	Univariate OR (95%CI)	P value	Multivariate OR (95%CI)	P value
Age > 75, yes	0.69 (0.30-1.56)	0.37	-	-	0.48 (0.19-1.24)	0.13	-	-
Sex, male, yes	1.40 (0.66-32.94)	0.38	-	-	0.79 (0.39-1.62)	0.79	-	-
BMI >28 kg/m2, yes	0.19 (0.02-1.44)	0.11	-	-	0.42 (0.09-1.94)	0.42	-	-
Background, HCC	-	Ref.			-	Ref.
CCC & CHC	0.30 (0.09-1.08)	0.07	0.31 (0.08-1.17)	0.08	0.81 (0.31-2.07)	0.65	-	-
Colorectal liver metastasis	0.98 (0.41-2.38)	0.96	0.88 (0.35-2.21)	0.79	0.88 (0.34-2.27)	0.79	-	-
Others	0.76 (0.31-2.37)	0.76	0.93 (0.30-2.88)	0.90	0.97 (0.35-2.71)	0.96	-	-
HCV positive, yes	0.63 (0.29-1.38)	0.25	-	-	1.18 (0.58-2.39)	0.65
Diabetes mellitus, yes	0.93 (0.47-1.83)	0.84	-	-	0.77 (0.39-1.52)	0.45	-	-
Renal complication, yes	2.50 (0.73-8.60)	0.15	-	-	0.51 (0.11-2.37)	0.39	-	-
Heavy alcoholic, yes	1.10 (0.56-2.18)	0.77	-	-	0.86 (0.44-1.69)	0.66	-	-
Preoperative platelet count < 100 × 103/L, yes	2.19 (0.47-10.13)	0.32			5.30 (1.22-23.09)	0.03	5.01 (1.14-21.95)	0.03
Preoperative ALBI score (per 1.0 up)	2.85 (1.21-6.71)	0.02	2.80 (1.17-6.69)	0.02	2.33 (1.05-5.18)	0.04	2.27 (1.01-5.09)	0.04
ICG 15 minutes rate (per 1.0 up)	0.97 (0.93-1.01)	0.15	-	-	1.00 (0.97-1.04)	0.92	-	-
Liver cirrhosis (F4), yes	1.22 (0.47-23.14)	0.69	-	-	1.42 (0.51-3.97)	0.51	-	-
Preoperative chemotherapy, yes	0.66 (0.25-1.73)	0.40	-	-	0.84 (0.32-2.24)	0.73	-	-
Re-hepatectomy, yes	2.65 (0.84-8.33)	0.09	2.81 (0.84-9.47)	0.09	0.28 (0.04-2.25)	0.23	-	-
Liver resection percentage (per 1.0% up)	1.01 (0.99-1.04)	0.22	-	-	1.01 (0.99-1.04)	0.24	-	-
Intraoperative blood loss > 1000mL, yes	1.73 (0.83-3.62)	0.14	-	-	1.04 (0.47-2.34)	0.92	-	-
RBC transfusion, yes	0.75 (0.20-2.82)	0.67	-	-	0.81 (0.22-3.02)	0.75	-	-
Pringle time > 90 min, yes	1.07 (0.49-2.34)	0.86	-	-	1.09 (0.51-2.31)	0.83	-	-
Posthepatectomy liver failure grade B/C, yes	0.58 (0.16-2.10)	0.41	-	-	0.72 (0.21-2.93)	0.72	-	-
Postoperative complication CD grade ≥ 3, yes	0.31 (0.11-0.84)	0.02	0.29 (0.10-0.82)	0.02	1.79 (0.83-3.87)	0.14	-	-

OR: Odds ratio; BMI: Body mass index; HCC: Hepatocellular carcinoma; CCC: Cholangiocellular carcinoma; CHC: Combined hepatocellular carcinoma and cholangiocellular carcinoma; HCV: Hepatitis C virus; ALBI: Albumin-bilirubin; ICG: Indocyanine green; RBC: Red blood cell; CD: Clavien-Dindo.