Preoperative albumin-bilirubin score and liver resection percentage determine postoperative liver regeneration after partial hepatectomy

Table 1 Demographics, n (%)

	RH/Tri group (n = 41)	LH group (n = 53)	Seg group (n = 99)	Sub/Non group (n = 75)	P value
Baseline characteristics
Age	68 (16-80)	69 (14-86)	68 (46-83)	70 (52-90)	0.06
Sex, male, yes	29 (71)	33 (62)	73 (74)	58 (77)	0.29
BMI (kg/m2)	21.8 (15.4-31.3)	22.3 (15.2-29.4)	230 (15.5-32.8)	23.4 (17.8-35.5)	0.009
Background disease
HCC	21 (51)	14 (26)	63 (64)	56 (75)	< 0.001
CCC & CHC	4 (10)	19 (36)	9 (9)	8 (11)	-
Colorectal liver metastasis	10 (24)	6 (11)	16 (16)	11 (15)	-
Others	6 (15)	14 (26)	11 (11)	0 (0)	-
HCV, yes	6 (15)	9 (17)	26 (26)	29 (39)	0.01
Liver resection percentage	52 (21-71)	32 (13-49)	27 (10-56)	15 (10-32)	< 0.001
Diabetes mellitus, yes	13 (32)	16 (30)	34 (34)	33 (44)	0.36
Renal complication	3 (7)	3 (6)	6 (6)	6 (8)	0.94
Heavy alcoholic1	15 (37)	9 (17)	39 (39)	32 ()	0.03
ICG 15 min	10.7 (0.1-81.1)	9.0 (1.4-66.4)	10.1 (1.3-80.0)	11.5 (2.8-33.4)	0.65
Preoperative ALBI score	-2.56 (-3.46 to -1.40)	-2.73 (-3.50 to -0.69)	-2.85 (-3.75 to -1.51)	-2.78 (-3.38 to -1.82)	0.07
Preoperative platelet count (/uL)	205 (95-562)	198 (78-504)	186 (61-542)	182 (91-396)	0.02
Liver cirrhosis (F4), yes	4 (10)	2 (4)	18 (18)	9 (12)	0.08
Laparoscopic hepatectomy	3 (7)	2 (38)	13 (13)	7 (9)	0.28
Re-hepatectomy	3 (7)	4 (8)	5 (5)	7 (9)	0.74
Preoperative Chemotherapy	10 (24)	9 (17)	15 (15)	5 (7)	0.06
Postoperative outcomes
Operation time (min)	383 (218-644)	354 (183-629)	388 (151-742)	341 (153-584)	0.008
Intraoperative blood loss (mL)	680 (110-13360)	378 (68-3660)	525 (0-32150)	470 (0-1894)	0.25
RBC transfusion	6 (15)	3 (6)	8 (8)	3 (4)	0.19
Total Pringle time (min)	56 (0-179)	45 (0-131)	75 (0-202)	78 (0-167)	< 0.001
Posthepatectomy liver failure grade B/C	10 (24)	3 (6)	7 (7)	3 (4)	0.001
Complication CD grade ≥ 3	9 (22)	10 (19)	22 (22)	12 (16)	0.75
Length of Hospital stay (d)	16 (7-41)	11 (5-54)	11 (6-40)	11 (6-167)	0.46

¹Daily alcohol consumption 30 g/d or higher.

RH/Tri: Right hepatectomy/Trisegmentectomy; LH: Left hepatectomy; Seg: Segmentectomy; Sub/Non: Subsegmentectomy and nonanatomical hepatectomy; BMI: Body mass index; HCC: Hepatocellular carcinoma; CCC: Cholangiocellular carcinoma; CHC: Combined hepatocellular carcinoma and cholangiocellular carcinoma; HCV: Hepatitis C virus; ALBI: Albumin-bilirubin; ICG: Indocyanine green; RBC: Red blood cell; CD: Clavien-Dindo.