Growth differentiation factor-15 serum concentrations reflect disease severity and anemia in patients with inflammatory bowel disease

Figure 1 Correlation and comparison. A: Correlation between growth-differentiation factor-15 (GDF-15) serum levels and simple endoscopic score for Crohn’s disease (CD) in patients with CD (Spearman’s rank correlation coefficient); B: Correlations between GDF-15 serum levels and ulcerative colitis endoscopic index of severity in patients with ulcerative colitis (Spearman’s rank correlation coefficient); C: Correlation between GDF-15 and C-reactive protein in the total studied population (Spearman’s rank correlation coefficient); D and E: Correlation between GDF-15 and indicators of anemia in the total studied population: Serum iron levels (D) and hemoglobin (E) (Spearman’s rank correlation coefficient); F: Comparison of serum GDF-15 concentrations with respect to the presence of anemia in patients with inflammatory bowel disease (Mann-Whitney U test). GDF-15: Growth-differentiation factor-15; SES-CD: Simple endoscopic score for Crohn’s disease; UCEIS: Ulcerative colitis endoscopic index of severity; UC: Ulcerative colitis; IBD: Inflammatory bowel disease; Hb: Hemoglobin; CRP: C-reactive protein.