Early proactive monitoring of DNA-thioguanine in patients with Crohn’s disease predicts thiopurine-induced late leucopenia in NUDT15/TPMT normal metabolizers

Figure 6 Performance of early DNA-thioguanine and 6-thioguanine nucleotides concentrations in the prediction of late leucopenia in the entire population, nudix hydrolase 15/thiopurine methyltransferase wild-type and heterozygous subgroups. A: Performance in the entire population; B: Performance in nudix hydrolase 15 (NUDT15)/thiopurine methyltransferase (TPMT) wild-type subgroups; C: Performance in NUDT15/TPMT heterozygous subgroups. 6TGN: 6-thioguanine nucleotides; DNATG: DNA-thioguanine; AUC: Area under the curve; FPR: False positive rate; TPR: True positive rate.