Early proactive monitoring of DNA-thioguanine in patients with Crohn’s disease predicts thiopurine-induced late leucopenia in NUDT15/TPMT normal metabolizers

Figure 5 Early DNA-thioguanine concentration was significantly associated with late leucopenia, especially in thiopurine methyl-transferase/nudix hydrolase 15 wild-type patients compared to 6-thioguanine nucleotides. A: Early DNA-thioguanine concentration was associated with late leucopenia, especially in nudix hydrolase 15 (NUDT15)/thiopurine methyltransferase (TPMT) wild-type patients (P = 4.9 × 10^-9vs P = 0.024); B: 6-thioguanine nucleotides was correlated with late leucopenia in NUDT15/TPMT wild-type patients (P = 0.018) but not in heterozygous subgroups (P =0.55). P values were determined by the Mann-Whitney test. 6TGN: 6-thioguanine nucleotides; DNATG: DNA-thioguanine; RBC: Red blood cell.