Early proactive monitoring of DNA-thioguanine in patients with Crohn’s disease predicts thiopurine-induced late leucopenia in NUDT15/TPMT normal metabolizers

Figure 4 Early DNA-thioguanine concentration was associated with late leucopenia with immense significance compared to 6-thioguanine nucleotides. A: Patients who developed leucopenia had much higher early DNA-thioguanine levels compared with those who did not (P = 4.9 × 10^-13); B: Patients who developed leucopenia had slightly higher early 6-thioguanine nucleotides levels compared with those who did not (P = 0.021). P values were determined by the Mann-Whitney test. 6TGN: 6-thioguanine nucleotides; DNATG: DNA-thioguanine.