Early proactive monitoring of DNA-thioguanine in patients with Crohn’s disease predicts thiopurine-induced late leucopenia in NUDT15/TPMT normal metabolizers

Figure 3 Correlation between early 6-thioguanine nucleotide concentration and peripheral leukocyte, neutrophil, lymphocyte, and monocyte counts. A-H: There was no significant correlation between early 6-thioguanine nucleotides (6TGN) concentration, and the minimum or average peripheral leukocyte, neutrophil, and lymphocyte counts during follow-up (P > 0.05) (A-C, E-G). There was a correlation between early 6TGN concentration and the minimum or average peripheral monocyte counts (P < 0.05) (D and H). P values were determined by the nonparametric Spearman test. 6TGN: 6-thioguanine nucleotides; RBC: Red blood cell.