Early proactive monitoring of DNA-thioguanine in patients with Crohn’s disease predicts thiopurine-induced late leucopenia in NUDT15/TPMT normal metabolizers

Figure 2 Correlation between early DNA-thioguanine concentration and peripheral leukocyte, neutrophil, lymphocyte, and monocyte counts. A-D: There was a significant negative correlation between early DNA-thioguanine (DNATG) concentration, and the minimum peripheral leukocyte, neutrophil, lymphocyte, and monocyte counts during follow-up; E-H: A marginally significant negative correlation was found between early DNATG concentration and the average peripheral leukocyte, neutrophil, lymphocyte, and monocyte counts. P values were determined by the nonparametric Spearman test. DNATG: DNA-thioguanine.