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©The Author(s) 2024.
World J Gastroenterol. Mar 28, 2024; 30(12): 1751-1763
Published online Mar 28, 2024. doi: 10.3748/wjg.v30.i12.1751
Published online Mar 28, 2024. doi: 10.3748/wjg.v30.i12.1751
Table 1 Baseline characteristics of the 148 patients included in the study
Characteristics | Patients | P value | Odds ratio (95%CI) | |
Leucopenia | Nonleucopenia | |||
Number of subjects (%) | 42 (28.4) | 106 (71.6) | ||
Female, n (%) | 14 (33.3) | 22 (20.8) | 0.11 | 1.91 (0.86-4.23) |
Age (yr) | 29 (12-59) | 26 (13-61) | 0.03 | 0.96 (0.92-0.99) |
Azathioprine, n (%) | 37 (26.6) | 102 (73.4) | Reference | 0.29 (0.07-1.14) |
6-mercaptopurine, n (%) | 5 (55.6) | 4 (44.4) | 0.08 | 1.05 (1.01-1.10) |
Thiopurine dose (mg) | 87.5 (25-100) | 75 (50-150) | 0.76 | 0.99 (0.98-1.01) |
Azathioprine | 75 (25-100) | 75 (50-150) | ||
6-mercaptopurine | 50 (37.5-50) | 37.5 (25-50) | ||
Weight (kg) | 52 (40-69) | 55 (37-79) | 0.02 | 1.05 (1.01-1.10) |
Hematologic indices | ||||
Leukocyte count (109/L) | 6.25 (4.09-16.66) | 6.92 (4.09-17.60) | 0.83 | 1.31 (0.11-15.71) |
Absolute neutrophil count (109/L) | 3.98 (1.30-15.55) | 4.59 (1.91-14.76) | 0.78 | 0.70 (0.06-8.31) |
Absolute lymphocyte count (109/L) | 1.64 (0.41-4.45) | 1.53 (0.27-4.26) | 0.79 | 0.94 (0.57-1.53) |
Monocyte count (109/L) | 0.49 (0.22-1.98) | 0.57 (0.10-1.72) | 0.66 | 1.29 (0.42-3.91) |
Hemoglobin (g/L) | 126 (76-165) | 130 (66-166) | 0.43 | 1.01 (0.99-1.02) |
Platelets (109/L) | 287 (122-589) | 302 (150-680) | 0.10 | 1.00 (0.99-1.01) |
Comedication (%) | ||||
Anti-TNF agents | 2 (4.76) | 16 (15.09) | 0.49 | 0.46 (0.05-4.09) |
Corticosteroids | 2 (4.76) | 5 (4.72) | 0.76 | 1.41 (0.16-12.47) |
Genotypes (phenotypes) | ||||
NUDT15*1/*1 (NM) | 18 (42.86) | 93 (87.74) | Reference | |
NUDT15*1/*3 (IM) | 13 (30.95) | 8 (7.55) | 0.95 | 0.97 (0.34-2.72) |
NUDT15*1/*2 (IM) | 9 (21.43) | 5 (4.72) | 0.61 | 1.42 (0.37-5.44) |
NUDT15*1/*6 (IM) | 2 (4.76) | 0 | 0.99 | |
TPMT*1/*1 (NM) | 40 (95.24) | 105 (99.06) | Reference | |
TPMT*1/*3C (IM) | 2 (4.76) | 1 (0.94) | 0.19 | 0.94 (0.47-2.35) |
- Citation: Yang T, Chao K, Zhu X, Wang XD, Chan S, Guan YP, Mao J, Li P, Guan SX, Xie W, Gao X, Huang M. Early proactive monitoring of DNA-thioguanine in patients with Crohn’s disease predicts thiopurine-induced late leucopenia in NUDT15/TPMT normal metabolizers. World J Gastroenterol 2024; 30(12): 1751-1763
- URL: https://www.wjgnet.com/1007-9327/full/v30/i12/1751.htm
- DOI: https://dx.doi.org/10.3748/wjg.v30.i12.1751