Assessing recent recurrence after hepatectomy for hepatitis B-related hepatocellular carcinoma by a predictive model based on sarcopenia

Table 3 Univariate and multivariate Cox proportional hazard models of hepatocellular carcinoma recurrence after hepatectomy involving whether pathological factors in the training cohort

Variable	Univariate analysis			Multivariate analysis without pathological factors			Multivariate analysis with pathological factors
	HR	95%CI	P value	HR	95%CI	P value	HR	95%CI	P value
Male	1.038	0.58-1.858	0.9
Age (yr)	0.991	0.975-1.007	0.255
Sarcopenia	1.61	1.073-2.416	0.022	1.814	1.196-2.751	0.005	1.819	1.199-2.759	0.005
Liver cirrhosis (yes, no)	0.888	0.593-1.328	0.562
Liver capsular invasion	1.289	0.863-1.927	0.215
ALT (U/L)	1	0.997-1.002	0.746
Total bilirubin (mmol/L)	0.994	0.975-1.014	0.577
Albumin (g/L)	0.971	0.942-1.001	0.061
INR	1.055	0.951-1.171	0.312
MVI	1.663	1.13-2.449	0.01
Tumor differentiation
Well	Ref.
Moderate	1.764	1.127-2.76	0.013
Poor	1.93	1.115-3.34	0.019
Maximum diameter of tumor
≤ 3 cm	Ref.			Ref.			Ref.
3-5 cm	1.063	0.542-2.087	0.858	1.134	0.576-2.233	0.715	1.151	0.585-2.268	0.684
> 5 cm	2.202	1.277-3.796	0.005	2.286	1.322-3.952	0.003	2.228	1.288-3.852	0.004
HBV-DNA
< 2000 IU/mL	Ref.			Ref.			Ref.
≥ 2000 IU/mL	2.007	1.358-2.966	< 0.001	2.191	1.468-3.272	< 0.001	2.162	1.45-3.223	< 0.001
AFP ≥ 40 ng/mL	1.92	1.269-2.904	0.002	2.032	1.322-3.952	< 0.001	1.823	1.198-2.773	0.005

MVI: Microvascular invasion; HBV-DNA: Hepatitis B virus deoxyribonucleic acid; AFP: Alpha-fetoprotein; ALT: Alanine aminotransferase; INR: International normalized ratio; PLT: Platelet count.