MicroRNAs: A novel signature in the metastasis of esophageal squamous cell carcinoma

Table 2 MicroRNAs act as oncogene in esophageal squamous cell carcinoma metastasis

miRNA	Metastasis studies in different sources			Ref.
oncomiR	Tissue	Cell	Xenograft
miR-10b-3p	LNM, C stages	I, M, EMT	Lung, Liver Bone Me	[56,57]
miR-10b	NS (LNM)	I, M		[229]
miR-103a-2-5p		I		[68]
miR-105-5p		I, M		[69]
miR-106b-5p	TNM	I, M, EMT	Lung Me	[52]
miR-1179	Me TNM	I		[232]
miR-1269	LNM, TNM	I, M		[59]
miR-1290	LNM, tumor invasion, TNM	I, M		[113]
miR-130b		I, M		[70]
miR1323		I, M		[71]
miR-135b-5p	LNM	I, M		[236]
MiR-140-5p		I, M, EMT		[92]
miR-142-3p	LNM			[237]
miR-1470		M		[239]
miR-17-5p	LNM, TNM, DI	I, M		[60,240]
miR-17a	LNM, C stage			[242]
miR-18a	LNM, TNM	I, M		[61,244]
miR-181b-5p	Advance TNM	M		[107]
miR-181c-3p	DI, TNM			[246]
miR-19b	LNM, C stage			[242]
miR-19b-3p		I, M		[72]
miR-196a		I, M		[74]
miR-196a-3p		M		[74]
miR-20b-5p	LNM, C stage	I, M		[249]
miR200a		I, M		[87]
miR-211	LNM, LI, VI, TNM	I, M, EMT		[282]
miR-221		I, M		[251]
miR-224	NR (LNM), TNM	I, M		[252]
miR-224-5p		I, M, EMT		[100]
miR-23a	NS	I, M	Lung Me	[140,254]
miR-23b-3p		I, M, EMT		[73]
MiR-23b-5p	Me	I, M	Lung Me	[257]
miR-25	LNM, TNM	I, M, EMT	Lung Me	[58]
miR-25-3p	LNM, TNM	I, M		[62]
miR-30d-5p	LNM, TNM, DI	I, M, EMT		[91,230]
miR-301	LNM, TNM	I, M		[63]
miR-301a-3p	LNM, tumor invasion, TNM			[231]
miR-301b		I, M		[75]
miR-31	N, M stage, TNM	I, M, EMT		[233]
miR-320b	LNM	I, M, EMT		[53]
miR-330-3p		I, M		[234]
miR-3656		I, M		[235]
miR-373	LNM, TNM	I, M		[64]
miR-425		I, M		[119]
miR-4286		I, M		[238]
miR-4443	TNM	I		[60]
miR-452-5p	LNM, DM	I, M		[241]
miR-483-3p		I, M, EMT		[243]
miR-483-5p	LNM, TNM	I, M		[65,66]
miR-506	LNM, TNM			[245]
miR-5692b	DI, TNM			[246]
miR-602	LNM, TNM	I, M	Lung, liver, bone, adrenal gland Me	[54]
miR-612	LNM, metastasis	I, M		[247]
miR-624-3p		I, M, EMT		[76]
miR-675-3p		I, M, EMT		[248]
miR-766-3p	LNM, TNM	I, M		[67]
miR-875-5p		I, M		[250]
miR-9	LNM	I, M, EMT	Lung Me	[85]
miR-92a	LNM, LNI	I, M		[86]
miR-92a-3p		I, M		[77]
miR-92b-3p		I, M		[253]
miR-935	Me			[255]
miR93		I, M		[256]

¹NS (plasma).

LNM: Lymph node metastasis; VI: Vessel invasion; LNI: Lymph node invasion; LI: Lymphatic invasion; TNM: Tumor nodes metastasis stage; C stage: Clinical stage; DI: Depth of invasion; I: Invasion; M: Migration; Me: Metastasis; EMT: Epithelial-mesenchymal transition.