Review
Copyright ©The Author(s) 2024.
World J Gastroenterol. Mar 21, 2024; 30(11): 1497-1523
Published online Mar 21, 2024. doi: 10.3748/wjg.v30.i11.1497
Table 1 MicroRNAs act as suppressor in esophageal squamous cell carcinoma metastasis
miRNA
Metastasis studies in different sources
Ref.
Suppressor
Tissue
Cell
Xenograft
miR-1LNM, VI, TNM, advanced C stageI[148]
miR-10aLNM, C stageI, M, EMTTumor Me[29]
miR-100LNMI, M[24]
miR-100-5pDI, LI, T stage[149]
miR-101LNMI, MLiver Me[30]
miR-10527-5pLNM, T stage, LII, M, EMT,[9]
LI
miR-107NS (LNM)I, M[152]
miR-122I, M, EMT[116]
miR-124LNM, MeI, M[25]
miR-124-3pLNM, DI, DM, TNM I, M, EMT[31,156]
miR-125a-5pI, M[157]
miR-125bLNM, TNMI, M, EMT[26]
miR-1254 VI, P stage[159]
miR-126LNM, TNMI, M[27]
miR-128-3pLNMI, M, EMT[23]
miR-129TNMI, M[28,143]
miR-129-2LNM, DM, advance clinical TNMI, M[164]
MiR-129-2-3pI, M[166]
miR-1294LNM, LI, VII, M[84]
miR-130a-5pI, M[169]
miR-133aLNM, P stage I, M[170]
miR-133bI, M, EMT[102]
miR-134LNM, TNMI, M[32]
miR-136-5pLNM, TNMI, M[168]
miR-137I, M, EMT[174]
miR-138LNM, TNM[18]
miR-140-3pLNM, DM, TNMI, EMT[176]
miR-140MeI, M, EMT[178]
miR-143LNM, DI, VI, TNMI, M[13]
miR-143-3pI, M[180]
miR-144Me, TNMI, MLiver Me[33]
miR-145LNM, DI, TNMI, M, EMT[182, 183]
miR-145-3pI, M[185]
miR-145-5pI, M, EMT[187]
miR-146aNS (N stage), TNMI, M, EMT[189]
miR1469LNM, DI[191]
miR-148aI, M, EMT[193]
miR-149-5pI, M[10]
miR-150LNM, LI, VI, TNMI, M, EMT[195]
miR-150-3pI, M[197]
miR-153I, M, EMT[94]
miR-181a-5pI, MDLA Me[199]
miR-185NS (LNM, DM, TNM)I, MLung Me[15]
miR-186-5pNS (LNM), DMI, M[43]
miR-193a-5pLNM, TNM[19]
miR-193bI, M[104]
miR-195LNM, VI, TNMI, M[202]
miR-198I, M[204]
miR-202LNMM[206]
miR203LNM, TNMI, M, EMTLung Me[34,81]
miR-203a-3pI, M, EMT[209]
miR-204-5pLNM, DII, M, EMT[210]
miR-205LNMI, M, EMT[93,213]
miR206LNM, TNM[20]
miR-212-3pI[215]
miR-214LNM, tumor stageI, M, EMT[216,217]
miR-214-3pI, M[219]
miR-216a/bLNM, TNM[220]
miR-217I, M[80]
miR-218LNM, TNMI, M[221]
miR-26aLNM, C stagesI, MLiver Me[33,223]
miR-27aLNMI[103]
miR-27b-3pLNM, TNMI, M, EMT[225]
miR-29bLNMI, M[88]
miR-29cMPI[228]
miR-30aLNMI, M[148]
miR-30bNS (N stage)I, M, EMT[44]
miR30a-3pLNMI, M, EMT[148]
miR-30cT, N, M, stageI, EMT[95]
miR-30dLNM, advanced TNMI, M[150]
miR-30e-5I, M[126]
miR-301aI, M[151]
miR-323a-3pI, MLung Me[153]
miR-326I, M[154]
miR-328I, MLiver Me[155]
miR-33a-5pLNM, TNMI, M[111]
miR-335-5pI, M, EMT[158]
miR-338-3pI, M, EMT[101]
miR-338-5pI, MLung Me[160]
miR-34aLNM, TNMI, M, EMTLiver Me[36,161]
miR-340-5pLNM, TNMI, M[162]
miR-3612I, M[163]
miR-365I, EMT[165]
miR-370LNM, tumor invasion[167]
miR-370-3pLNM, TNMI, M[168]
miR-375LNM, LVI, DM, TNMI, M, EMTTumor mobility, I[37,38]
miR-377LNM, TNMI, M[171]
miR378LNM, TNMI, M,[172]
miR-378a-3pI, M[11]
miR-422aI, M[173]
miR-429LNM, TNMI, M, EMT[175]
miR-4324LNM, DII, M, EMT[175]
miR-433-3pI, M[177]
miR-4429 LNM, TNMI, M, EMT[114]
miR-449a-5pLNM, TNM[179]
miR-451 LNM, TNM[21]
miR-455-3pLNMI[181]
miR-455-5pLNMI, M[184]
miR-4766-5pI, M, EMT[186]
miR-485-5pNS (LNM), TNMI, M, EMT[188]
miR-486-5pI[190]
miR-490-3pI, M, EMT[192]
miR-493I, M[145]
miR-497-5pI, M[194]
miR-498NS (LNM, DM)I, M[196]
miR-508-3pI, M[198]
miR-515-3pMeI, M, EMTLung ME[12]
miR-516bLNM, DI, advanced TNMI, M, EMT[200]
miR-518bLNMI[201]
miR-542-3pNS (metastasis)I, M[47]
miR-574-3pLNM, DI, TNMI, M[50]
miR-590LNM, TNMI, M, EMT[51]
miR-595I, M[203]
miR-599I, M, EMT[205]
miR-615-5pLNM, advanced TNMI, M[207]
miR-620I, M, EMTLung ME[208]
miR-622N stage, TNMI, M, EMT[138]
miR-625LNM, DM, advanced TNMI[211,212]
miR-630LNM, P stageI, M, EMT[214]
miR-652LNM, TNMI, MMultiple ME[39]
miR-670-3pI, M[139]
miR-671-5pI, M, EMT[218]
miR-718LNM, TNM[22]
miR-765I, M[133]
miR-874-3pLNM, C stageI, M[14]
miR-942-5pTNM, C stageI, M, EMT[222]
miR-98LNM, TNMI, M[216]
miR-99aI, M, EMT[224]
let-7LNM[226]
let-7aTNMI, M, EMTLNM[227]
let-7b-5pI, M[40]
LNM: Lymph node metastasis; VI: Vessel invasion; LVI: Lymphatic vessel invasion; LI: Lymphatic invasion; TNM: Tumor nodes metastasis stage; C stage: Clinical stage; P stage: Pathological stage; DI: Depth of invasion; DM: Distant metastasis; I: Invasion; M: Migration; EMT: Epithelial-mesenchymal transition; Me: Metastasis; DLA Me: Dilated lymphatic arteries metastasis; Multiple Me: Brain, bone, adrenal gland, lung, kidney, liver metastasis; MPI: Muscularis propria invasion.