Serotonin receptor 2B induces visceral hyperalgesia in rat model and patients with diarrhea-predominant irritable bowel syndrome

Figure 8 RS12-7445 decreased the transient receptor potential vanilloid type 1 levels in colon tissues in irritable bowel syndrome with diarrhea rats. A: Immunohistochemical staining showing the expression of transient receptor potential vanilloid type 1 (TRPV1) in the colon mucosa layer and colon muscular layer of each group. Magnification 20 ×; B: Levels of TRPV1 mRNA in colon mucosa layer tissues were measured by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR); C: Levels of TRPV1 mRNA in colon muscular layer tissues were measured by qRT-PCR. ^aP < 0.05. IBS-D: Irritable bowel syndrome with diarrhea; TRPV1: Transient receptor potential vanilloid type 1.