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©The Author(s) 2024.
World J Gastroenterol. Mar 14, 2024; 30(10): 1346-1357
Published online Mar 14, 2024. doi: 10.3748/wjg.v30.i10.1346
Published online Mar 14, 2024. doi: 10.3748/wjg.v30.i10.1346
Figure 5 Dose-response relationship between the cumulative effects of excess high-normal alanine aminotransferase levels and the risk of new-onset metabolic dysfunction-associated fatty liver disease.
A: Equally weighted cumulative effects of excess high-normal alanine aminotransferase (ehALT) levels; B: Unequally weighted cumulative effects of ehALT. The equally and unequally weighted cumulative effects of ehALT had a positive nonlinear relationship with the risk of new-onset metabolic dysfunction-associated fatty liver disease in approximately 95% of the enrolled participants. Gray histogram: The probability distribution of the population corresponding to the accumulation of ehALT. Orange solid line: The restricted cubic splines [hazard ratios (HRs)]. Black dashed curves: The 95% confidence interval of the restricted cubic splines (HRs). Green dashed line: The reference line of the restricted cubic splines (HR = 1). Blue dashed lines: The dividing lines indicating population proportions of less than 5%, 3%, and 1%, respectively. MAFLD: Metabolic dysfunction-associated fatty liver disease; ehALT: Excess high-normal alanine aminotransferase; HR: Hazard ratio.
- Citation: Chen JF, Wu ZQ, Liu HS, Yan S, Wang YX, Xing M, Song XQ, Ding SY. Cumulative effects of excess high-normal alanine aminotransferase levels in relation to new-onset metabolic dysfunction-associated fatty liver disease in China. World J Gastroenterol 2024; 30(10): 1346-1357
- URL: https://www.wjgnet.com/1007-9327/full/v30/i10/1346.htm
- DOI: https://dx.doi.org/10.3748/wjg.v30.i10.1346