Shear-wave elastography to predict hepatocellular carcinoma after hepatitis C virus eradication: A systematic review and meta-analysis

Table 5 Predictive liver stiffness threshold for development of hepatocellular carcinoma after sustained virologic response and relative adjusted hazard ratio and area under the curve

Ref.	LS threshold in kPa	SWE timing	aHR (95%CI)	P value	AUC
Hamada et al[31], 2018	≥ 11.0	24 wk after EOT	28.71 (2.58-320.03)	0.006	0.93
Gyotoku et al[32], 2022	Not reported	24 wk after EOT	Not reported	Not reported	0.86
Kumada et al[35], 2022	11.7	Baseline	28.08 (5.53-132.60)	< 0.001	0.93
Masaoka et al[33], 2023	7.0	12 wk after EOT	Not reported	Not reported	Not reported
Nicoletti et al[34], 2023	ΔLS < 20%	Baseline and 48 wk after EOT	2.98 (1.01-8.11)	0.03	0.69

ΔLS = Baseline liver stiffness (LS) – LS at 48 wk. 95%CI: 95% Confidence interval; aHR: Adjusted hazard ratio; AUC: Area under the curve; EOT: End of treatment; FU: Follow-up; HCC: Hepatocellular carcinoma; SVR: Sustained virological response; SWE: Shear-wave elastography.