Cumulative effects of excess high-normal alanine aminotransferase levels in relation to new-onset metabolic dysfunction-associated fatty liver disease in China

doi:10.3748/wjg.v30.i10.1346

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Gastroenterol. Mar 14, 2024; 30(10): 1346-1357
Published online Mar 14, 2024. doi: 10.3748/wjg.v30.i10.1346

Table 2 Baseline characteristics of 3553 participants on follow-up

Variables	Total (3553)	lALT group (2409)	hALT group (1046)	aALT group (98)	F/χ²^/H	P value
Sex, n (%)					264.16	< 0.001
Male	1741 (49.00)	955 (39.64)	712 (68.07)	74 (75.51)
Female	1812 (51.00)	1454 (60.36)	334 (31.93)^a	24 (24.49)^a
Age (yr), mean (SD)	48.39 (15.13)	47.82 (15.39)	50.17 (14.54)^a	43.51 (12.59)^a^,^b	14.11	< 0.001
WC (cm), mean (SD)	85.81 (1.81)	85.79 (1.67)	85.85 (1.94)	85.85 (3.11)	0.44	0.643
SBP (mmHg), mean (SD)	120.33 (16.66)	119.18 (16.64)	122.93 (16.70)^a	121.08 (13.41)	18.77	< 0.001
DBP (mmHg), mean (SD)	72.68 (10.27)	71.70 (10.03)	74.81 (10.60)^a	74.07 (8.92)^a	35.09	< 0.001
BMI (kg/m²), mean (SD)	22.80 (2.41)	22.46 (2.39)	23.46 (2.32)^a	23.94 (2.21)^a	76.76	< 0.001
SUA (μmol/L), mean (SD)	290.53 (72.07)	280.17 (69.87)	311.33 (71.51)^a	323.01 (74.16)^a	82.00	< 0.001
TC (mmol/L), mean (SD)	4.53 (0.84)	4.51 (0.82)	4.58 (0.88)^a	4.55 (0.84)	2.72	0.066
TG (mmol/L), median (IQR)	0.97 (0.72, 1.29)	0.93 (0.70, 1.26)	1.06 (0.79, 1.40)^a	1.09 (0.82, 1.52)^a	79.73	< 0.001
HDL-C (mmol/L), mean (SD)	1.47 (0.34)	1.50 (0.34)	1.42 (0.34)^a	1.39 (0.39)^a	18.51	< 0.001
LDL-C (mmol/L), mean (SD)	2.77 (0.75)	2.74 (0.73)	2.85 (0.78)^a	2.83 (0.72)	7.76	< 0.001
FPG (mmol/L), median (IQR)	4.96 (4.68, 5.25)	4.95 (4.67, 5.21)	5.00 (4.71, 5.30)^a	4.94 (4.65, 5.27)^b	10.65	0.005
HbA1c (%), median (IQR)	5.70 (5.50, 5.70)	5.70 (5.50, 5.70)	5.70 (5.40, 5.70)	5.70 (5.40, 5.70)^a^,^b	10.69	0.005

^aP < 0.05, compared with the low-normal alanine aminotransferase level group.

^bP < 0.05, compared with the high-normal alanine aminotransferase level group.

lALT: Low-normal alanine aminotransferase; hALT: High-normal alanine aminotransferase; aALT: Abnormal alanine aminotransferase; WC: Waist circumference; SBP: Systolic blood pressure; DBP: Diastolic blood pressure; BMI: Body mass index; TC: Total cholesterol; FPG: Fasting plasma glucose; HbA1c: Glycated haemoglobin; TG: Triglycerides; HDL-C: High-density lipoprotein cholesterol; LDL-C: Low-density lipoprotein cholesterol; SUA: Serum uric acid; IQR: Interquartile range.

Citation: Chen JF, Wu ZQ, Liu HS, Yan S, Wang YX, Xing M, Song XQ, Ding SY. Cumulative effects of excess high-normal alanine aminotransferase levels in relation to new-onset metabolic dysfunction-associated fatty liver disease in China. World J Gastroenterol 2024; 30(10): 1346-1357
URL: https://www.wjgnet.com/1007-9327/full/v30/i10/1346.htm
DOI: https://dx.doi.org/10.3748/wjg.v30.i10.1346