Crohn’s disease as the intestinal manifestation of pan-lymphatic dysfunction: An exploratory proposal based on basic and clinical data

Figure 1 Flowchart for Crohn’s disease as the intestinal manifestation of pan-lymphatic dysfunction. The following factors are considered: inside-out model, fatty acid/bile acid metabolism, cellular/molecular mechanisms, and zebrafish as a novel fine animal model. CD: Crohn’s disease; PBA: Primary bile acid; SBA: Second bile acid.