Treat to target in Crohn’s disease: A practical guide for clinicians

Table 1 Time to treatment targets based on Crohn’s disease therapy

	Mean time to treatment target (wk)1
	Clinical response	Clinical remission	Normalisationof CRP	Decrease in calprotectin	Endoscopic healing
Anti-TNF	2-4[4]	4-6[4]	9[4]	11[4]	17[4]
Adalimumab	2-4[114]	4[114]	-	-	12[114]
Infliximab	2-4[115,116]	4-6[4]	-	-	24[117,118]
Exclusive enteral nutrition	2[119]	4-8[119-121]	5[4]	8[4]	4-8[120,121]
Methotrexate	9[122]	22[122]	14[4]	15[4]	24[4]
Oral steroids	2-4[20]	4-7[4,123]	5[4]	8[4]	-
Thiopurine	12[124]	15-18[4,125]	15[4]	17[4]	26[118]
Upadacitinib	2[126]	2-4[126]	-	-	12-16[127]
Ustekinumab	6[128]	6-8[128]	11[4]	14[4]	19[4]
Vedolizumab	6-14[129-132]	10-14[133-135]	15[4]	17[4]	22[136]

¹In the absence of high-quality data, the time to response data should only be used as a guide.

TNF: Tumour necrosis factor; CRP: C-reactive protein.