Pharmacokinetics of four 5-FU preparations administered rectally to rats and rabbits

doi:10.3748/wjg.v3.i4.249

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Dec 15, 1997 (publication date) through Sep 27, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 15, 1997; 3(4): 249-250
Published online Dec 15, 1997. doi: 10.3748/wjg.v3.i4.249

Table 2 Main pharmacokinetic parameters in rabbits after rectal administration of four 5-FU preparations (^-x ± s, n = 3)

Group	T1/2 (h)	Vd (L)	AUC [(mg·g)/L]	Cmax (mg/L)	Tmax (h)
HBS	1.19 ± 0.52	2.25 ± 1.01	95.41 ± 45.21^b	39.56 ± 19.02	0.84 ± 0.41
LBS	1.92 ± 0.80	16.90 ± 7.44	20.44 ± 9.82	8.56 ± 3.70	0.55 ± 0.29
SE	4.54 ± 1.75	22.98 ± 10.51	35.60 ± 15.03	9.95 ± 3.97	0.40 ± 0.17
CE	2.10 ± 0.98	3.00 ± 1.42	126.19 ± 73.35^b	30.48 ± 15.24	0.99 ± 0.49

^bP < 0.01 HBS group vs LBS group, CE group vs SE group. HBS: hydrophil-based (polyethylene glycols) suppositories; LBS: Lipophil-based (semi-synthetic fatty glyceride) suppositories SE: Simple (o/w) emulsion; CE: Complex (w/o/w) emulsion.

Citation: Zhang X, Wang CS, Wu GZ, Ling BD, Liang RH, Fang XS, Xin TY. Pharmacokinetics of four 5-FU preparations administered rectally to rats and rabbits. World J Gastroenterol 1997; 3(4): 249-250
URL: https://www.wjgnet.com/1007-9327/full/v3/i4/249.htm
DOI: https://dx.doi.org/10.3748/wjg.v3.i4.249