Pharmacokinetics of four 5-FU preparations administered rectally to rats and rabbits

doi:10.3748/wjg.v3.i4.249

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Dec 15, 1997 (publication date) through Sep 27, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 15, 1997; 3(4): 249-250
Published online Dec 15, 1997. doi: 10.3748/wjg.v3.i4.249

Table 1 Comparison of tissue concentrations in rats among the four 5-FU preparations (^-x ± s, n = 5)

Group	Concentration
Group	Plasma (mg/L)	Rectal wall (mg/g)	Mesenteric lymph nodes (mg/g)
HBS	27.10 ± 15.06^c	71.97 ± 21.64^b	75.92 ± 21.81^b
LBS	16.60 ± 15.03	46.82 ± 20.84^b	41.93 ± 17.22^b
SE	14.39 ± 9.40	154.11 ± 46.54^a^b	41.29 ± 15.30^b
CE	19.47 ± 8.71^c	156.60 ± 42.31^a^b	46.45 ± 13.41^b

^bP < 0.01 vs plasma level;

^aP < 0.05 SE group vs HBS group, CE group vs LBS group;

^cP > 0.05 HBS group vs LBS group, CE group vs SE group. HBS: hydrophil-based (polyethylene glycols) suppositories; LBS: Lipophil-based (semi-synthetic fatty glyceride) suppositories SE: Simple (o/w) emulsion; CE: Complex (w/o/w) emulsion.

Citation: Zhang X, Wang CS, Wu GZ, Ling BD, Liang RH, Fang XS, Xin TY. Pharmacokinetics of four 5-FU preparations administered rectally to rats and rabbits. World J Gastroenterol 1997; 3(4): 249-250
URL: https://www.wjgnet.com/1007-9327/full/v3/i4/249.htm
DOI: https://dx.doi.org/10.3748/wjg.v3.i4.249