Effects of endotoxin on expression of ras, p53 and bcl-2 oncoprotein in hepatocarcinogenesis induced by thioacetamide in rats

Table 1 Oncogene ras p21 expression and DNA content in the various study groups

Group	n	FI, x ± s	% cells labeled, x ± s	Cases with positive ras p21expression	DNA index, x ± s
Sham	5	1	17 ± 4	1	1
TAA control	6	1.29 ± 0.085	18 ± 5	6	1.15 ± 0.21
TAA + LPS	6	1.60 ± 0.071a	24 ± 7a	6	1.24 ± 0.25a
TAA + ST	6	1.52 ± 00105a	15 ± 3b	6	1.44 ± 0015ab
TAA + ST + LPS	6	1.32 ± 0.061bc	49 ± 9abc	6	1.56 ± 0.07abc
CBRH-7919 cells	1	1.54	42	1	1.34

^aP < 0.02 vs TAA control group;

^bP < 0.02 vs TAA + LPS group; FI: fluorescence index;

^cP < 0.02 vs TAA + ST group. CBRH-7919: rat hepatocarcinoma cell line; DNA index: ratio of mean nuclear DNA content of the treated rat to mean DNA content of normal rats.