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Copyright ©The Author(s) 2023.
World J Gastroenterol. Mar 7, 2023; 29(9): 1446-1459
Published online Mar 7, 2023. doi: 10.3748/wjg.v29.i9.1446
Table 1 Noncoding RNAs in the pathogenesis and progression of liver fibrosis
ncRNAs
Target genes
Signaling pathways
Ref.
miR-199a-3pCAV2 TGF-β/Smad [20]
miR-497Smad7TGF-β/Smad [17]
miR-21Smad2/3/7 TGF-β/Smad [15]
TGF-βPI3K/AKT[25]
-PPARα[51]
-PDCD4/AP-1[51,52]
-Smad7/Smad2/3/NOX4, Spry1/ERK/NF-κB [51,53]
-HIF-1α/VEGF[54]
miR-16Smad2, Wnt3aTGF-β/Smad, Wnt [18]
miR-130a-3pTGF-βRI, TGF-βRII; MAPK1TGF-β; MAPK[22]
miR-98-5pTGF-βRITGF-β1/Smad3 [19]
miR-6133-5pTGF-βRII, FGFRITGF-β/Smad2/3, AKT/ERK/JNK [55]
miR-708ZEB1Wnt/β-catenin [29]
exo-miR-1297PTENPI3K/AKT [26]
miR-350SPRY2 PI3K/AKT and ERK [56]
miR-34cACSL1-[57]
miR-200cHAS2 -[58]
miR-451, miR-185EphB2 -[42]
miR-20b-5pSTAT3STAT3[97]
lncRNA SNHG7miR-29b, DNMT3A Autophagy pathway [40]
lncRNA PVT1miR-152, ATG14 Autophagy pathway [39]
lncRNA SCARNA10PRC2TGF-β[23]
lncRNA LOC102551149miR-23a-5p, PTENPI3K/AKT/mTOR/Snail[27]
lncRNA MALAT1-Wnt/β-catenin[31]
lncRNA NEAT1miR-139-5p, β-catenin β-catenin/SOX9/TGF-β1[30]
miR-129-5p, PEG3NF-κB[32]
miR-129-5p, SOCS2-[33]
miR-148a-3p, miR-22-3p, Cyth3-[34]
lncRNA Lfar1-NF-κB[35]
lncRNA GAS5miR-433-3p, TLR10 NF-κB [36]
lncRNA-RORmiR-6499-3pNF-κB [99]
lncRNA AirnEZH2KLF2-eNOS-sGC[98]
lncRNA MEG3NLRC5 -[37]
lncRNA NORADmiR-495-3p, S1PR3 -[60]
lncRNA XISTmiR-539-3p, ADAMTS5 -[44]
lncRNA Mical2miR-203a-3p, p66Shc -[43]
circRNA608miR222, PINK1 Autophagy pathway [41]
circMTO1miR-17-5p, Smad7-[24]
circFBXW4miR-18b-3p, FBXW7-[48]
circCREBBPmiR-1291, LEFTY2 -[49]
circ_0071410miR-9-5p-[50]
circUbe2kmiR-149-5p, TGF-β2-[59]