Better performance of PIVKA-II for detecting hepatocellular carcinoma in patients with chronic liver disease with normal total bilirubin

Figure 4 Comparisons of receiver operating characteristic curves of serum protein induced by vitamin K absence or antagonist-II for diagnosing early-stage hepatocellular carcinoma in subgroups of alkaline phosphatase and total bilirubin for patients with viral etiology. A: Between alkaline phosphatase (ALP) ≤ 1 × upper limit of normal (ULN) and ALP > 1 × ULN subgroups; B: Between total bilirubin (TBIL) ≤ 1 × ULN and TBIL > 1 × ULN subgroups. ULN: Upper limit of normal; TBIL: Total bilirubin; ALP: Alkaline phosphatase; AUC: Area under the receiver operating characteristic curve.