Stress granules inhibit endoplasmic reticulum stress-mediated apoptosis during hypoxia-induced injury in acute liver failure

Figure 3 Effect of stress granules on apoptosis, HIF-1α, and lactate dehydrogenase in hepatocyte hypoxia model through endoplasmic reticulum stress. A: The level of mRNA in cells was detected by quantitative real-time polymerase chain reaction; B and C: The level of apoptosis was detected by flow cytometry; D-E: The detection kits were used to evaluate the content of HIF-1α in homogenates, lactate dehydrogenase in cell supernatant. n = 3. Data was shown mean ± SD. ^aP < 0.05 vs normal group; ^bP < 0.05 vs hypoxia group; ^cP < 0.05 vs hypoxia + siRNA-ATF4.