Burden of bone disease in chronic pancreatitis: A systematic review and meta-analysis

Table 4 Metaregression of outcome measures with various covariates

Covariates	Osteopenia		Osteoporosis		Fragility fracture
	95%CI	P value	95%CI	P value	95%CI	P value
Sex distribution	0.2 (-1.2-1.5)	P = 0.8	0.5 (-1.9-2.9)	P = 0.7	0.3 (-3.2-3.7)	P = 0.9
Age	0.0 (0-1)	P = 0.6	0.0 (-0.1-0.0)	P = 0.3	0.0 (-0.5-0.4)	P = 0.7
DM	0.3 (-5.5-6.0)	P = 0.9	0.0 (-3.9-3.8)	P = 0.9	-13.8 (-107.4-79.8)	P = 0.3
Alcohol use	0.0 (-1.5-1.3)	P = 0.1	0.8 (-8.5-10.0)	P = 0.7	-0.5 (-5.4-4.4)	P = 0.3
Vitamin D	0.0 (-0.02-0.0012)	P = 0.4	-0.002 (-0.004-0.001)	P = 0.2	0.0 (-0.003-0.005)	P = 0.5
PTH levels	0.002 (-0.02-0.02)	P = 0.5	0.0 (-0.02-0.03)	P = 0.4	-	-
PERT	1.7 (0.6 -2.8)	P = 0.2	1.7 (0.6-2.8)	P < 0.0001	1.0 (-4.3-6.2)	P = 0.5
Smoking	0.0 (-3.6-3.6)	P = 0.9	-0.5 (-2.9-1.9)	P = 0.6	2.0 (-3.4-7.9)	P = 0.3
Mean BMI	NA	P = 0.9	0.0 (-0.12-0.21)	P = 0.6	0.5 (-17.2-18.2)	P = 0.8

DM: diabetes mellitus; PTH: Parathyroid; PERT: Pancreatic enzyme replacement; NA: P value calculated through Monte Carlo permutation, coefficient not available; -: Insufficient values.