Minireviews
Copyright ©The Author(s) 2023.
World J Gastroenterol. Feb 28, 2023; 29(8): 1304-1314
Published online Feb 28, 2023. doi: 10.3748/wjg.v29.i8.1304
Table 3 Major and minor criteria for the diagnosis of Cowden syndrome[37]
Major criteria
Minor criteria
Breast malignancy Fibrocystic changes of the breast
Lhermitte-Duclos diseaseFibromas
Macrocephaly Gastrointestinal hamartomas
Thyroid malignancyGenitourinary tumors or malformations
Lipomas
Mental retardation
Thyroid lesions, i.e. goiter