Influence of methyl donor nutrients as epigenetic regulators in colorectal cancer: A systematic review of observational studies

doi:10.3748/wjg.v29.i7.1219

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World Journal of Gastroenterology

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World J Gastroenterol. Feb 21, 2023; 29(7): 1219-1234
Published online Feb 21, 2023. doi: 10.3748/wjg.v29.i7.1219

Table 2 Characteristics of the cohort study included in this systematic review examining the interactive effects between single-nucleotide polymorphisms in genes encoding methyl-metabolizing enzymes and one-carbon metabolism-related dietary compounds on colorectal cancer risk

Ref.	Country	Study cohort (age, yr)	No. participants (M/W)	No. incident cases	Follow-up length, y	Gene (SNP)	Nutrient/alcohol	Method for measuring nutrition intake	Outcome (RR, 95%CI)			Adjustments to RR	NOS
Ref.	Country	Study cohort (age, yr)	No. participants (M/W)	No. incident cases	Follow-up length, y	Gene (SNP)	Nutrient/alcohol	Method for measuring nutrition intake	SNP	Nutrient/alcohol	Interaction	Adjustments to RR	NOS
de Vogel et al[9]	Netherlands	Netherlands Cohort Study on diet and cancer (55-69)	58279/62573	734 CRC	7.3	MTHFR (rs1801133, rs1801131), MTR (rs1805087), MTRR (rs1801394), DNMT3B (rs2424913, rs406193), EHMT1 (rs4634736), EHMT2 (rs535586), PRDM2 (rs2235515)	Dietary folate, Met, vitamins B₂ and B₆, alcohol	Validated FFQ (self-reported)	Unk	Unk	≤ 1 rare allele in folate metabolizing enzymes–vitamin B₂ (T₃vs T₁): 0.30, (0.11-0.81), P-trend = 0.005. Rare allele of DNMT3B C>T (rs406193)–vitamin B₆ (T₃vs T₁): 1.90 (1.00-3.60), P-trend = 0.04. Common allele of PRDM2 G>A (rs2235515)–vitamin B₆ (T₃vs T₁): 1.49 (1.00-2.22), P-trend = 0.03. No assoc	Age, alcohol consumption, BMI, CRC family history, intake of energy and alcohol, sex, and smoking status	9

Asso: Significant association; BMI: Body mass index; CI: Confidence interval; CRC: Colorectal cancer; DNMT3B: ADN (cytosine-5-)-methyltransferase 3 ; EHMT1: Euchromatin histone methyltransferase 1; FFQ: Food frequency questionnaire; M: Men; MTHFR: Methylenetetrahydrofolate reductase; MTR: Methionine synthase; MTRR: Methionine synthase reductase; NOS: Quality Newcastle-Ottawa Scale; PRDM2: PR domain zinc finger protein 2; RR: Relative risk; SNP: Single-nucleotide polymorphism; T: Tertile; unk: Unknown; W: Women.

Citation: Chávez-Hidalgo LP, Martín-Fernández-de-Labastida S, M de Pancorbo M, Arroyo-Izaga M. Influence of methyl donor nutrients as epigenetic regulators in colorectal cancer: A systematic review of observational studies. World J Gastroenterol 2023; 29(7): 1219-1234
URL: https://www.wjgnet.com/1007-9327/full/v29/i7/1219.htm
DOI: https://dx.doi.org/10.3748/wjg.v29.i7.1219