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©The Author(s) 2023.
World J Gastroenterol. Feb 14, 2023; 29(6): 1109-1122
Published online Feb 14, 2023. doi: 10.3748/wjg.v29.i6.1109
Published online Feb 14, 2023. doi: 10.3748/wjg.v29.i6.1109
Table 2 Drugs used in the treatment of coronavirus disease 2019 that have adverse effects on the liver
| Drug(s) | Mechanism of action | Adverse effects on the liver | Ref. |
| Hydroxychloroquine | Increases intracellular pH and inhibits lysosomal activity in antigen-presenting cells | Liver failure | [51,52] |
| Lopinavir/Ritonavir | Inhibition of 3-chymotrypsin-like protease | Hepatoxicity | [53] |
| Remdesivir | Inhibits viral transcription and replication by blocking the RNA polymerase enzyme | Increased aminotransferase levels | [54-57,70] |
- Citation: Fernandes S, Sosa-Napolskij M, Lobo G, Silva I. Relation of COVID-19 with liver diseases and their impact on healthcare systems: The Portuguese case. World J Gastroenterol 2023; 29(6): 1109-1122
- URL: https://www.wjgnet.com/1007-9327/full/v29/i6/1109.htm
- DOI: https://dx.doi.org/10.3748/wjg.v29.i6.1109