Saccharomyces cerevisiae prevents postoperative recurrence of Crohn's disease modeled by ileocecal resection in HLA-B27 transgenic rats

Figure 1 Study design. HLA-B27 transgenic rats (Tg) and wild-type rats (nTg) were randomized to receive phosphate buffered saline (n = 10), Saccharomyces cerevisiae (S. cerevisiae) CNCM I-3856 (n = 14), adherent-invasive Escherichia coli strain LF82 (n = 13), or S. cerevisiae CNCM I-3856 and LF82 (n = 27) by oral gavage from week (W) 10 or 11 to W18. Ileocecal resection was performed at W12, and animals were sacrificed at W18. Streptomycin (dotted line) was given on the last 3 d of W10 in all rats. Luminal (arrows) and/or adherent (dotted arrows) LF82 was quantified weekly during the 8-wk study. CFU: Colony-forming unit; PBS: Phosphate buffered saline; ICR: Ileocecal resection; d: Day.