Single-cell analysis identifies phospholysine phosphohistidine inorganic pyrophosphate phosphatase as a target in ulcerative colitis

Figure 2 Alterations in transcriptional profiles across different cell types during ulcerative colitis. A: Heatmap showing the distribution of upregulated differential expression genes (DEGs) (adjusted P value ≤ 0.05, Log2FC ≥ 0.25) for each cell type between healthy and ulcerative colitis groups (diseased/healthy); B: Heatmap showing the gene function annotations of upregulated DEGs; C: Heatmap showing the distribution of downregulated DEGs (adjusted P value ≤ 0.05, Log2FC ≤ 0.25) for each cell type between healthy and ulcerative colitis groups (diseased/healthy); D: Heatmap showing the gene function annotations of downregulated DEGs; E: Ring heatmap showing the top 100 upregulated DEGs during ulcerative colitis; F: Ring heatmap showing the top 100 downregulated DEGs during ulcerative colitis.