Gene targeted and immune therapies for nodal and gastrointestinal follicular lymphomas

Table 2 Lugano staging of gastrointestinal tract lymphoma[60]

Stage
I	Tumor confined to GI tract
	Primary site or multiple, non-contiguous lesions
II	Tumor extends into the abdomen from primary GI site
	Nodal involvement
II1	Local: Paragastric in cases of gastric lymphoma and para-intestinal for intestinal lymphoma
II2	Distant: Mesenteric in case of an intestinal primary lymphoma; otherwise paraaortic, paracaval, pelvic, or inguinal
IIE	Penetration of serosa involving adjacent organs or tissues: Enumerate sites of involvement, e.g., IIE (pancreas), IIE (large intestine), IIE (post-intestinal wall)
	Where there is nodal involvement and penetration involving adjacent organs, the stage is denoted using a subscript (1 or 2) and E, e.g., II1E (pancreas)
IV	Disseminated extra-nodal involvement or a GI tract lesion with supradiaphragmatic nodal involvement

GI: Gastrointestinal.