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©The Author(s) 2023.
World J Gastroenterol. Dec 14, 2023; 29(46): 6060-6075
Published online Dec 14, 2023. doi: 10.3748/wjg.v29.i46.6060
Published online Dec 14, 2023. doi: 10.3748/wjg.v29.i46.6060
Figure 5 Oncogenic effect of exosomal circ563 prevented by either miR-148a-3p upregulation or metal-regulatory transcription factor-1 knockdown.
A-P: Exosomal circ563 promoted Hep3B cell proliferation and invasion, which were reversed by miR-148a-3p overexpression or metal-regulatory transcription factor-1 depletion. Group 1: Co-culturing Hep3B cells with mesenchymal stem cell (MSC)-derived exosomes; Group 2: Co-culturing Hep3B cells with exosomes derived from circ563-overexpressing MSCs; Group 3: Co-culturing Hep3B cells after miR-148a-3p upregulation with exosomes derived from circ563-overexpressing MSCs; and Group 4: Co-culturing Hep3B cells after metal-regulatory transcription factor-1 knockdown with exosomes derived from circ563-overexpressing MSCs. aP < 0.05, bP < 0.01, cP < 0.001.
- Citation: Lyu ZZ, Li M, Yang MY, Han MH, Yang Z. Exosome-mediated transfer of circRNA563 promoting hepatocellular carcinoma by targeting the microRNA148a-3p/metal-regulatory transcription factor-1 pathway. World J Gastroenterol 2023; 29(46): 6060-6075
- URL: https://www.wjgnet.com/1007-9327/full/v29/i46/6060.htm
- DOI: https://dx.doi.org/10.3748/wjg.v29.i46.6060