Pien Tze Huang alleviates Concanavalin A-induced autoimmune hepatitis by regulating intestinal microbiota and memory regulatory T cells

Figure 9 Species differences in intestinal microbiota and correlation analysis. A: Differential analysis among the four groups at the genus level; B: Phylotypes significantly different between the control and Concanavalin A (Con A) groups at the genus level; C: Phylotypes significantly different between Con A and Con A + middle-dose Pien Tze Huang groups at the genus level; D: Redundancy analysis of relationship between toll-like receptor (TLR)4, aspartate aminotransferase (AST), alanine aminotransferase (ALT), HAI, CD4⁺CD25⁺Foxp3⁺, CD4⁺CD45RA^-Foxp3^high and intestinal microbiota; E: Distance-based redundancy analysis of relationship between TLR4, AST, ALT, HAI, CD4⁺CD25⁺Foxp3⁺(regulatory T cells) cells, CD4⁺CD45RA^-Foxp3^high (memory regulatory T cells) cells, and intestinal microbiota; F: Spearman’s correlation heatmap of TLR4, AST, ALT, HAI, CD4⁺CD25⁺Foxp3⁺, CD4⁺CD45RA^-Foxp3^high and intestinal microbiota; G: The quantitative analysis of TLR4 protein expression. Data are representative images or the mean ± SEM (n = 6). ^aP < 0.05 and ^bP < 0.01 vs the control group; ^cP < 0.05 and ^dP < 0.01 vs the Concanavalin A group. ConA: Concanavalin A; PTH: Pien Tze Huang; DXM: Dexamethasone.