Pien Tze Huang alleviates Concanavalin A-induced autoimmune hepatitis by regulating intestinal microbiota and memory regulatory T cells

Figure 6 Pien Tze Huang regulates the number of memory T cells in mice with autoimmune hepatitis. A: Peripheral blood mononuclear cells; B: CD4+ lymphocytes measured by flow cytometry; C: CD45RA⁺ lymphocytes measured by flow cytometry; D: CD45RA^- lymphocytes measured by flow cytometry; E: CD4⁺CD45RA⁺CCR7⁺ cells. E1-E4: Control, Concanavalin A (Con A), Con A + middle-dose Pien Tze Huang (PTH-M), and Con A + dexamethasone (DXM) group in order; E5: Statistical analysis of CD4⁺CD45RA⁺CCR7⁺ cell frequencies in these four groups; F: CD4⁺CD45RA⁺CCR7^- cells. F1-F4: Control, Con A, Con A + PTH-M, and Con A + DXM group, respectively; F5: Statistical analysis of CD4⁺CD45RA⁺CCR7^- cell frequencies in these four groups; G: CD4⁺CD45RA^-CCR7⁺ cells. G1-G4: Control, Con A, Con A + PTH-M, and Con A + DXM group, respectively; G5: Statistical analysis of CD4⁺CD45RA^-CCR7⁺ cell frequencies in these four groups; H: CD4⁺CD45RA^-CCR7^-cells. H1-H4: Control, Con A, Con A + PTH-M, and Con A + DXM group, respectively; H5: Statistical analysis of CD4⁺CD45RA^-CCR7^- cell frequencies in these four groups. Data are representative images or the mean ± SEM (n = 8). ^aP < 0.05 and ^bP < 0.01 vs the control group; ^cP < 0.05 and ^dP < 0.01 vs the Concanavalin A group. ConA: Concanavalin A; PTH: Pien Tze Huang; DXM: Dexamethasone.