Pien Tze Huang alleviates Concanavalin A-induced autoimmune hepatitis by regulating intestinal microbiota and memory regulatory T cells

Figure 2 Pien Tze Huang relieves liver injury induced by Concanavalin A in mice. A: Timeline of the experimental process of treatment and autoimmune hepatitis induction in mice; B-E: Images of mouse livers (B), liver weigh (C), liver weigh index (D), and scores for liver injury (E) in different groups. According to the Ishak scoring system, liver injury was scored with respect to portal and intralobular inflammation, fragmented necrosis, and bridging necrosis. The extent of the pathology was scored from 0 (no pathology) to 4 (severe pathology); F: Representative photographs of hematoxylin and eosin-stained liver sections. Data are representative images or the mean ± SEM (n = 8). ^aP < 0.05 and ^bP < 0.01 vs the control group; ^cP < 0.05 and ^dP < 0.01 vs the Concanavalin A group. ConA: Concanavalin A; PTH: Pien Tze Huang; DXM: Dexamethasone.