Tousled-like kinase 1 promotes gastric cancer progression by regulating the tumor growth factor-beta signaling pathway

Figure 5 Tousled-like kinase 1 drives gastric cancer progression by modulating the tumor growth factor-beta signaling pathway. A and B: Genes positively and negatively correlated with Tousled-like kinase 1 (TLK1) were identified from The Cancer Genome Atlas database; C: Kyoto Encyclopedia of Genes and Genomes analysis identifying the differentially expressed genes and their associated enriched pathways; D: Gene set enrichment analysis of pathway enrichment; E–G: Western blot evaluating tumor growth factor-beta expression in gastric cancer cell lines in response to TLK1 knockdown or overexpression. ^aP < 0.05. TGF-beta: Tumor growth factor-beta; shNC: Short hairpin RNA of negative control; NC: Negative control; OE: Overexpression.