Tousled-like kinase 1 promotes gastric cancer progression by regulating the tumor growth factor-beta signaling pathway

Figure 1 Tousled-like kinase 1 was upregulated and localized mainly to the nucleus in gastric cancers. A: Tousled-like kinase 1 (TLK1) expression in various tumors was explored using The Cancer Genome Atlas database; B and C: Western blot measuring TLK1 expression in normal gastric epithelial cells GES-1 and in gastric cancer (GC) cell lines; D and E: Western blot detecting differential TLK1 expression between GC and adjacent non-neoplastic tissues; F: Immunofluorescence detecting subcellular TLK1 compartmentalization in HGC27 and MGC803 cell lines. ^aP < 0.05. TLK1: Tousled-like kinase 1; CHOL: Cholangiocarcinoma; COAD: Colon adenocarcinoma; ESCA: Esophageal carcinoma; PAAD: Pancreatic adenocarcinoma; STAD: Stomach adenocarcinoma.