Causal associations between inflammatory bowel disease and anxiety: A bidirectional Mendelian randomization study

Figure 2 Scatter plots of Mendelian randomization analysis showing the effect of ulcerative colitis and Crohn’s disease on anxiety. A: Analysis of ulcerative colitis (UC) and anxiety; B: Analysis of Crohn’s disease (CD) and anxiety. The x-axes represent the genetic instrument-UC or instrument-CD associations, and the y-axes represent genetic instrument-anxiety associations. Black dots denote the genetic instruments included in the primary Mendelian randomization (MR) analysis. Red: Inverse-variance weighted; Green: Weighted median; blue: MR Egger. CD: Crohn’s disease; UC: Ulcerative colitis; PGC: Psychiatric Genomics Consortium; SNP: Single-nucleotide polymorphism.