Changing trends and characteristics of peptic ulcer disease: A multicenter study from 2010 to 2019 in Korea

Table 3 Subgroup analysis of characteristics of peptic ulcer disease according to age, n (%)

	Age (yr)	H. pylori-related PUD (n = 8202)	Drug-related PUD (n = 7066)	Idiopathic PUD (n = 4333)	P value
Men	≥ 65	1161/2043 (56.8)	1869/3842 (48.6)	934/1601 (58.3)	< 0.001
	< 65	4107/6159 (66.7)	1905/3224 (59.1)	1813/2732 (66.4)	< 0.001
Gastric ulcer	≥ 65	1481/2043 (72.5)	2855/3842 (74.3)	1093/1601 (68.3)	< 0.001
	< 65	3581/6159 (58.1)	2197/3224 (68.1)	1665/2732 (60.9)	< 0.001
Duodenal ulcer	≥ 65	612/2043 (30.0)	1117/3842 (29.1)	561/1601 (35.0)	< 0.001
	< 65	2660/6159 (43.2)	1054/3224 (32.7)	1013/2732 (37.1)	< 0.001
Diagnosis
Hypertensive disorder	≥ 65	452/2043 (22.1)	1431/3842 (37.2)	321/1601 (20.0)	< 0.001
	< 65	476/6159 (7.7)	605/3224 (18.8)	208/2732 (7.6)	< 0.001
Diabetes mellitus	≥ 65	194/2043 (9.5)	610/3842 (15.9)	148/1601 (9.2)	< 0.001
	< 65	244/6159 (4.0)	344/3224 (10.7)	108/2732 (4.0)	< 0.001
Hyperlipidemia	≥ 65	201/2043 (9.8)	533/3842 (13.9)	53/1601 (3.3)	< 0.001
	< 65	386/6159 (6.3)	296/3224 (9.2)	76/2732 (2.8)	< 0.001
Chronic kidney disease	≥ 65	76/2043 (3.7)	382/3842 (9.9)	64/1601 (4.0)	< 0.001
	< 65	97/6159 (1.6)	222/3224 (6.9)	59/2732 (2.3)	< 0.001
Ischemic heart disease	≥ 65	247/2043 (12.1)	794/3842 (20.7)	35/1601 (2.6)	< 0.001
	< 65	236/6159 (3.8)	304/3224 (9.4)	14/2732 (0.6)	< 0.001
Cerebrovascular disease	≥ 65	92/2043 (4.5)	288/3842 (7.5)	25/1601 (1.6)	< 0.001
	< 65	69/6159 (1.1)	84/3224 (2.7)	10/2732 (0.5)	< 0.001
Chronic liver disease	≥ 65	42/2043 (2.3)	202/3842 (5.3)	120/1601 (7.5)	< 0.001
	< 65	182/6159 (3.0)	245/3224 (7.6)	229/2732 (8.4)	< 0.001
Alcoholic liver damage	≥ 65	20/2043 (1.1)	85/3842 (2.2)	64/1601 (4.0)	< 0.001
	< 65	144/6159 (2.3)	168/3224 (5.2)	170/2732 (6.2)	< 0.001
Liver cirrhosis	≥ 65	29/2043 (1.6)	161/3842 (4.2)	113/1601 (7.1)	< 0.001
	< 65	146/6159 (2.4)	220/3224 (6.8)	212/2732 (7.8)	< 0.001
Osteoarthritis	≥ 65	56/2043 (2.7)	145/3842 (3.8)	10/1601 (1.1)	< 0.001
	< 65	28/6159 (0.5)	46/3224 (1.6)	3/2732 (0.2)	< 0.001
Chronic obstructive lung disease	≥ 65	53/2043 (2.6)	176/3842 (4.6)	57/1601 (3.6)	0.001
	< 65	23/6159 (0.4)	33/3224 (1.0)	17/2732 (0.6)	0.001
Medication
Antiplatelet agent	≥ 65	324/2043 (15.9)	1058/3842 (27.5)	51/1601 (3.2)	< 0.001
	< 65	310/6159 (5.0)	456/3224 (14.1)	26/2732 (1.0)	< 0.001
Warfarin	≥ 65	49/2043 (2.4)	190/3842 (4.9)	28/1601 (1.9)	< 0.001
	< 65	35/6159 (0.6)	68/3224 (2.1)	6/2732 (0.3)	< 0.001
DOAC	≥ 65	23/2043 (1.2)	112/3842 (2.9)	19/1601 (1.2)	< 0.001
	< 65	10/6159 (0.2)	17/3224 (0.6)	1/2732 (0.1)	0.015
Steroid	≥ 65	237/2043 (11.6)	807/3842 (21.0)	111/1601 (6.9)	< 0.001
	< 65	453/6159 (7.4)	616/3224 (19.1)	116/2732 (4.2)	< 0.001
Antidepressant	≥ 65	456/2043 (22.3)	1568/3842 (40.8)	435/1601 (27.2)	< 0.001
	< 65	732/6159 (11.9)	840/3224 (26.1)	433/2732 (15.8)	< 0.001
Bisphosphonate	≥ 65	54/2043 (2.6)	174/3842 (4.5)	11/1601 (0.7)	< 0.001
	< 65	40/6159 (0.6)	49/3224 (1.5)	7/2732 (0.4)	< 0.001
Immunosuppressant	≥ 65	49/2043 (2.4)	108/3842 (2.8)	13/1601 (0.9)	< 0.001
	< 65	76/6159 (1.2)	167/3224 (5.2)	22/2732 (1.0)	< 0.001

PUD: Peptic ulcer disease; DOAC: Direct oral anticoagulant; H. pylori: Helicobacter pylori.