Location-based prediction model for Crohn’s disease regarding a novel serological marker, anti-chitinase 3-like 1 autoantibodies

Table 4 Association of anti-chitinase 3-like 1 autoantibodies antibody formation with clinical, serological, and genetic characteristics of Crohn’s disease at diagnosis and last follow-up

Anti-CHI3L1	IgA		sIgA
	OR (95%CI)	P value	OR (95%CI)	P value
At diagnosis
Complicated disease behaviour	1.86 (0.97-3.55)	0.081	2.37 (1.26-4.48)	0.009
Colon involvement	6.61 (2.29-19.07)	< 0.0001	2.09 (1.07-4.10)	0.038
ASCA IgA	4.11 (2.24-7.55)	< 0.0001	4.16 (2.40-7.19)	< 0.0001
OMP IgA	3.16 (1.79-5.57)	< 0.0001	2.64 (1.57-4.44)	< 0.0001
Anti-PS/PT IgA	3.46 (1.49-8.04)	0.005	2.56 (2.15-14.58)	< 0.0001
Anti-GP2 IgA	4.76 (0.87-26.18)	0.108	9.47 (1.12-79.52)	0.018
At last visit
Frequent relapse	2.56 (1.34-4.91)	0.005	1.89 (1.00-3.56)	0.047

Column corresponding to immunoglobulin G type anti-chitinase 3-like 1 autoantibodies and rows corresponding to age at onset, perianal disease at diagnosis, extraintestinal manifestations, NOD2/CARD15 mutations and therapy were omitted because statistically significant differences for a given parameter were not obtained. Positive associations are indicated in bold and negative associations are in italics (P values, odds ratio and 95% confidence interval). IgA: Immunoglobulin A; sIgA: Secretory immunoglobulin A; aCHI3L1: Anti-chitinase 3-like 1 autoantibodies; OR: Odds ratio; CI: Confidence interval; ASCA: Anti-Saccharomyces cerevisiae antibody; OMP: Outer membrane protein; Anti-PS/PT: Anti-phosphatidylserine/prothrombin antibody; Anti-GP2: Anti-glycoprotein 2 antibody.