Application of extended criteria donor grafts in liver transplantation for acute-on-chronic liver failure: A retrospective cohort study

Table 6 Univariable and multivariable Cox analysis of risk factors for overall survival

Variables	OR	Univariate analysis		OR	Multivariate analysis
		HR (95%CI)	P value		HR (95%CI)	P value
Donor characteristics
HBV (positive vs negative)	1.478	0.646-3.383	0.355
Death of trauma (yes vs no)	0.848	0.379-1.898	0.688
ECD (yes vs no)	1.053	0.465-2.386	0.901
No. of ECD features (≥ 2 vs < 2)	0.840	0.279-2.531	0.757
Operation characteristics
Blood loss (L)	1.271	1.137-1.421	0.000	1.276	1.123-1.449	0.000
Anhepatic phase (min)	1.009	0.989-1.028	0.381
Operation time (h)	1.002	0.746-1.345	0.990
IFLT (yes vs no)	0.822	0.111-6.107	0.848
EAD (yes vs no)	2.726	1.009-7.365	0.048	2.481	0.914-6.737	0.075
AKI (yes vs no)	1.882	0.830-4.269	0.130
Recipient characteristics
BMI (> 30 vs ≤ 30)	0.831	0.112-6.166	0.856
MELD (> 30 vs ≤ 30)	1.528	0.678-3.444	0.307
OFs (> 2 vs ≤ 2)	3.191	1.309-7.780	0.011	3.042	1.245-7.432	0.015
WBC (× 109/L)	1.007	0.897-1.129	0.912
N/L	1.040	0.992-1.090	0.102
Hb (g/L)	0.984	0.963-1.005	0.128
GGT (U/L)	0.986	0.968-1.005	0.142
ALB (g/L)	1.044	0.963-1.131	0.300
ALT (U/L)	0.992	0.984-1.001	0.070
AST (U/L)	0.998	0.992-1.004	0.463
PLT (× 109/L)	0.999	0.987-1.010	0.813
Fib (g/L)	0.874	0.345-2.211	0.775

OR: Odds ratio; CI: Confidence interval; HBV: Hepatitis B virus; ECD: Extended criteria donor; EAD: Early allograft dysfunction; BMI: Body mass index; IFLT: Ischemia-free liver transplantation; AKI: Acute kidney injury; MELD: Model for end-stage liver disease; OFs: Organ failures; WBC: White blood cell; Hb: Hemoglobin; GGT: Gamma glutamyltransferase; ALB: Albumin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; PLT: Platelets; Fib: Fibrinogen.