Advances and key focus areas in gastric cancer immunotherapy: A comprehensive scientometric and clinical trial review (1999-2023)

Table 2 Clinical trials in phase 3 and phase 4 (or phase 2/3)

No.	Trial ID	Status	Phases	Start date	Title
1	NCT00503321	Terminated	Phase 2/3	October 1, 2006	Phase II Study of TS-1 Therapy and TS-1+PSK Therapy Against Advanced Gastric Carcinoma
2	EUCTR2017-004896-30-IE	Not recruiting	Phase 3	July 6, 2018	A Randomized, Active-Controlled, Blinded, Phase III Clinical Trial of BMS- 986213 (Fixed Dose Combination of Relatlimab [anti-LAG-3] and Nivolumab) in Combination with Chemotherapy versus Placebo in Combination with Chemotherapy as First-Line Treatment in Participants with Unresectable, Locally Advanced or Metastatic LAG-3 Positive Gastric or Gastroesophageal Junction Adenocarcinoma
3	NCT04078152	Active, not recruiting	Phase 4	September 5, 2019	Durvalumab Long-Term Safety and Efficacy Study
4	ChiCTR2000039110	Recruiting	Phase 4	October 14, 2020	Effect of immunotherapy combined with chemotherapy on gastric cancer
5	NCT05002686	Recruiting	Phase 2/3	August 7, 2021	Safety and Efficacy of Sintilimab in Combination With Chemoradiothrapy Followed by D2 Surgical Resection in Patients With Advanced Gastric Cancer With Retroperitoneal Lymph Node Metastasis
6	NCT05152147	Recruiting	Phase 3	December 2, 2021	A Study of Zanidatamab in Combination With Chemotherapy Plus or Minus Tislelizumab in Patients With HER2-positive Advanced or Metastatic Gastric and Esophageal Cancers
7	NCT05270824	Not yet recruiting	Phase 3	March 1, 2022	Study Evaluating Neoadjuvant Immunotherapy Increasing CD8+ Cell Infiltration in Advance Gastric Adenocarcinoma
8	NCT05325528	Recruiting	Phase 2/3	April 4, 2022	Study of Tislelizumab in Combination With SOX for the Treatment of Gastric Cancer With Liver Metastases
9	NCT05677490	Not yet recruiting	Phase 3	January 6, 2023	mFOLFIRINOX Versus mFOLFOX With or Without Nivolumab for the Treatment of Advanced, Unresectable, or Metastatic HER2 Negative Esophageal, Gastroesophageal Junction, and Gastric Adenocarcinoma
10	NCT05699655	Not yet recruiting	Phase 2/3	March 1, 2023	Tislelizumab Combined With Apatinib and Oxaliplatin Plus S1 Vs Oxaliplatin Plus S1 as Neoadjuvant Therapy for Borrmann IV, Large Borrmann III Type and Bulky N Positive Advanced Gastric Cancer