Clinical significance of programmed cell death-ligand expression in small bowel adenocarcinoma is determined by the tumor microenvironment

Table 5 Univariate and multivariate Cox proportional hazards analysis for cancer-specific survival (n = 50)

Variables	Categories	Univariate analysis		Multivariate analysis
		HR (95%CI)	P value	HR (95%CI)	P value
Histological type	PD, Muc vs. WD, MD	2.252 (0.799-6.348)	NS
Depth	pT3-4 vs. pT1-2	39.308 (0.661-2337.048)	NS
Lymph node metastasis	Positive vs. negative	42.764 (5.639-324.314)	< 0.001	66.320 (7.494-586.923)	< 0.001
T-PD-L1	Positive vs. negative	0.733 (0.261-2.059)	NS
I-PD-L1	Positive vs. negative	0.367 (0.137-0.980)	0.046	1.156 (0.231-5.769)	NS
PD-L1 CPS ≥ 10	Positive vs. negative	0.621 (0.240-1.606)	NS
T-PD-L2	Positive vs. negative	0.702 (0.249-1.981)	NS
I-PD-L2	Positive vs. negative	0.243 (0.070-0.840)	0.025	0.113 (0.020-0.650)	0.015
PD-L2 CPS ≥ 10	Positive vs. negative	0.493 (0.191-1.276)	NS
FoxP3	High vs. low	1.067 (0.423-2.694)	NS
CD8	High vs. low	0.311 (0.111-0.872)	0.026	1.922 (0.164-22.481)	NS
FoxP3/CD8	High vs. low	4.490 (1.476-13.660)	0.008	1.476 (0.138-15.769)	NS

HR: Hazard ratio; 95%CI: 95% confidence interval; PD-L1: Programmed cell death-ligand 1; PD-L2: Programmed cell death-ligand 2; NS: Not significant.