Clinical significance of programmed cell death-ligand expression in small bowel adenocarcinoma is determined by the tumor microenvironment

Table 3 Clinicopathological correlation of CD8, FoxP3, and FoxP3/CD8

	No.	FoxP3		CD8		FoxP3/CD8
		N (%)	P value	N (%)	P value	N (%)	P value
Age
≤ 68	27	14 (51.9)	NS	14 (51.9)	NS	14 (51.9)	NS
> 68	23	11 (47.8)		11 (47.8)		11 (47.8)
Sex
Female	15	7 (46.7)	NS	8 (53.3)	NS	8 (53.3)	NS
Male	35	18 (51.4)		17 (48.6)		17 (48.6)
Site
Duodenum and jejunum	45	22 (48.9)	NS	23 (51.1)	NS	22 (48.9)	NS
Ileum	5	3 (60.0)		2 (40.0)		3 (60.0)
Histology
WD, MD	41	21 (51.2)	NS	21 (51.2)	NS	20 (48.8)	NS
PD, Muc	9	4 (44.4)		4 (44.4)		5 (55.6)
Depth
pT1-2	14	4 (28.6)	0.059	7 (50.0)	NS	4 (28.6)	0.059
pT3-4	36	21 (58.3)		18 (50.0)		21 (58.3)
Lymph node metastasis
Absence	27	11 (40.7)	NS	17 (63.0)	0.047	8 (29.6)	0.002
Presence	23	14 (60.9)		8 (34.8)		17 (73.9)
Distant metastasis
Absence	37	16 (43.2)	NS	22 (59.5)	0.024	14 (37.8)	0.004
Presence	13	9 (69.2)		3 (23.1)		11 (84.6)
Peritoneal seeding
Absence	40	19 (47.5)	NS	23 (57.5)	0.034	16 (40.0)	0.005
Presence	10	6 (60.0)		2 (20.0)		9 (90.0)
TNM stage
I	14	4 (28.6)	NS	7 (50.0)	NS	4 (28.6)	0.011
II	13	7 (53.8)		10 (76.9)		4 (30.8)
III	10	5 (50.0)		5 (50.0)		6 (60.0)
IV	13	9 (69.2)		3 (23.1)		11 (84.6)
MMR status
Proficient	43	19 (44.2)	0.049	20 (46.5)	NS	22 (51.2)	NS
Deficient	7	6 (85.7)		5 (71.4)		3 (42.9)

WD: Well differentiated; MD: Moderately differentiated; PD: Poorly differentiated; Muc: Mucinous adenocarcinoma; NS: Not significant.