Clinical significance of programmed cell death-ligand expression in small bowel adenocarcinoma is determined by the tumor microenvironment

Table 2 Clinicopathological correlation of programmed cell death-ligand 1 and programmed cell death-ligand 2 expression

	No.	T-PD-L1		I-PD-L1		PD-L1 CPS ≥ 10		T-PD-L2		I-PD-L2		PD-L2 CPS ≥ 10
		N (%)	P value	N (%)	P value	N (%)	P value	N (%)	P value	N (%)	P value	N (%)	P value
Age
≤ 68	27	10 (37.0)	NS	16 (59.3)	NS	14 (51.9)	NS	12 (44.4)	NS	14 (51.9)	NS	19 (70.4)	0.027
> 68	23	7 (30.4)		11 (47.8)		11 (47.8)		5 (21.7)		7 (30.4)		9 (39.1)
Sex
Female	15	4 (26.7)	NS	7 (46.7)	NS	7 (46.7)	NS	6 (40.0)	NS	8 (53.3)	NS	8 (53.3)	NS
Male	35	13 (37.1)		20 (57.1)		18 (51.4)		11 (31.4)		13 (37.1)		20 (57.1)
Site
Duodenum and jejunum	45	16 (35.6)	NS	25 (55.6)	NS	24 (53.3)	NS	16 (35.6)	NS	20 (44.4)	NS	26 (57.8)	NS
Ileum	5	1 (20.0)		2 (40.0)		1 (20.0)		1 (20.0)		1 (20.0)		2 (40.0)
Histology
WD, MD	41	13 (31.7)	NS	24 (58.5)	NS	21 (51.2)	NS	17 (41.5)	0.015	19 (46.3)	NS	26 (63.4)	0.030
PD, Muc	9	4 (44.4)		3 (33.3)		4 (44.4)		0 (0.0)		2 (22.2)		2 (22.2)
Depth of invasion
pT1-2	14	0 (0.0)	0.001	4 (28.6)	0.024	2 (14.3)	0.002	5 (35.7)	NS	6 (42.9)	NS	6 (42.9)	0.068
pT3-4	36	17 (47.2)		23 (63.9)		23 (63.9)		12 (33.3)		15 (41.7)		22 (61.1)
Lymph node metastasis
Absence	27	8 (29.6)	NS	16 (59.3)	NS	13 (48.1)	NS	8 (29.6)	NS	13 (48.1)	NS	15 (55.6)	NS
Presence	23	9 (39.1)		11 (47.8)		12 (52.2)		9 (39.1)		8 (34.8)		13 (56.5)
Distant metastasis
Absence	37	12 (32.4)	NS	22 (59.5)	NS	20 (54.1)	NS	13 (35.1)	NS	18 (48.6)	NS	23 (62.2)	0.095
Presence	13	5 (38.5)		5 (38.5)		5 (38.5)		4 (30.8)		3 (23.1)		5 (38.5)
Peritoneal seeding
Absence	40	14 (35.0)	NS	25 (62.5)	0.019	23 (57.5)	0.034	14 (35.0)	NS	19 (47.5)	NS	25 (62.5)	NS
Presence	10	3 (30.0)		2 (20.0)		2 (20.0)		3 (30.0)		2 (20.0)		3 (30.0)
TNM stage
I	14	0 (0.0)	0.008	4 (28.6)	0.005	2 (14.3)	0.001	5 (35.7)	NS	6 (42.9)	NS	6 (42.9)	NS
II	13	8 (61.5)		12 (92.3)		11 (84.6)		3 (23.1)		7 (53.8)		9 (69.2)
III	10	4 (40.0)		6 (60.0)		7 (70.0)		5 (50.0)		5 (50.0)		8 (80.0)
IV	13	5 (38.5)		5 (38.5)		5 (38.5)		4 (30.8)		3 (23.1)		5 (38.5)
MMR status
Proficient	43	12 (27.9)	0.037	20 (46.5)	0.009	18 (41.9)	0.005	15 (34.9)	NS	16 (37.2)	NS	22 (51.2)	NS
Deficient	7	5 (71.4)		7 (100.0)		7 (100.0)		2 (28.6)		5 (71.4)		6 (85.7)

PD-L1: Programmed cell death-ligand 1; PD-L2: Programmed cell death-ligand 2; CPS: Combined positive score; WD: Well differentiated; MD: Moderately differentiated; PD: Poorly differentiated; Muc: Mucinous adenocarcinoma; NS: Not significant.