Diagnostic and economic value of carcinoembryonic antigen, carbohydrate antigen 19-9, and carbohydrate antigen 72-4 in gastrointestinal cancers

Table 8 Diagnostic efficiencies of gastric cancer, colorectal cancer and gastrointestinal cancers at the traditional and best cut-off values

		Gastric cancer			Colorectal cancer			Gastrointestinal cancers
		CEA	CA19-9	CA72-4	CEA	CA19-9	CA72-4	CEA	CA19-9	CA72-4
	AUC	0.625	0.577	0.570	0.736	0.649	0.598	0.705	0.627	0.590
Traditional cut-off value	Cut-off value	5.0	37.0	6.0	5.0	37.0	6.0	5.0	37.0	6.0
	DOR	6.083	5.089	2.220	14.854	11.895	2.376	12.459	10.367	2.337
	Sensitivity	0.227	0.140	0.240	0.377	0.241	0.249	0.323	0.210	0.243
	Specificity	0.954	0.969	0.876	0.961	0.974	0.878	0.963	0.975	0.879
	Youden index	0.181	0.109	0.115	0.338	0.215	0.127	0.286	0.185	0.122
	Accuracy	0.945	0.959	0.868	0.945	0.954	0.861	0.938	0.945	0.854
	PPV	0.056	0.052	0.023	0.212	0.204	0.054	0.266	0.261	0.077
	NPV	0.990	0.989	0.990	0.982	0.979	0.977	0.972	0.968	0.966
	PLR	4.927	4.516	1.927	9.640	9.269	2.034	8.759	8.400	2.012
	NLR	0.810	0.888	0.868	0.649	0.779	0.856	0.703	0.810	0.861
Best cut-off value	Cut-off value	2.6	16.3	3.8	2.8	20.7	2.0	2.5	19.6	3.4
	DOR	2.687	2.233	2.038	6.345	4.825	1.933	4.419	3.872	2.068
	Sensitivity	0.423	0.324	0.349	0.558	0.361	0.566	0.556	0.339	0.375
	Specificity	0.785	0.823	0.791	0.834	0.895	0.597	0.779	0.883	0.775
	Youden index	0.209	0.147	0.141	0.392	0.256	0.163	0.335	0.222	0.150
	Accuracy	0.781	0.817	0.786	0.827	0.881	0.596	0.770	0.861	0.759
	PPV	0.023	0.022	0.020	0.086	0.088	0.038	0.094	0.107	0.065
	NPV	0.991	0.990	0.990	0.985	0.980	0.980	0.977	0.970	0.968
	PLR	1.972	1.833	1.675	3.363	3.445	1.405	2.519	2.900	1.667
	NLR	0.734	0.821	0.822	0.530	0.714	0.727	0.570	0.749	0.806

The best cut-off value referred to the threshold when the Youden index was the largest. CEA: Carcinoembryonic antigen; CA19-9: Carbohydrate antigen 19-9; CA72-4: Carbohydrate antigen 72-4; AUC: Area under the curve; DOR: Diagnostic odds ratio; PPV: Positive predictive value; NPV: Negative predictive value; PLR: Positive likelihood ratio; NLR: Negative likelihood ratio.