Diagnostic and economic value of carcinoembryonic antigen, carbohydrate antigen 19-9, and carbohydrate antigen 72-4 in gastrointestinal cancers

Table 12 Subgroup analysis of economic indicators

			Scheme 2							Scheme 1
			Cut-off value	Proportion of endoscopy	Missed diagnosis rate	Total cost ($)	Cost per capita ($)	Total C/E ($)	C/E per capita ($)	Total cost & C/E ($)	Cost & C/E per capita ($)
CEA	Whole	Whole	5.0	0.049	0.674	903.1	12.1	2770.9	37.1	3574.3	146.9
		≥ 80 yr	5.0	0.258	0.543	381.8	45.6	835.9	99.8	584.4	152.7
		≥ 75 yr	5.0	0.240	0.635	472.1	41.9	1294.7	115.0	623.2	151.8
		≥ 70 yr	5.0	0.214	0.627	463.5	37.7	1242.1	101.2	691.5	150.9
		≥ 65 yr	5.0	0.174	0.634	486.4	31.6	1329.1	86.3	844.6	149.9
		≥ 60 yr	5.0	0.137	0.636	523.6	25.8	1438.6	71.0	1099.1	149.0
		≥ 55 yr	5.0	0.110	0.639	574.1	21.6	1588.8	59.8	1424.3	148.3
		≥ 50 yr	5.0	0.085	0.643	662.6	17.7	1854.8	49.6	1972.8	147.6
		≥ 45 yr	5.0	0.065	0.658	758.5	14.6	2220.9	42.7	2614.6	147.2
		≥ 40 yr	5.0	0.055	0.668	837.4	13.1	2520.1	39.4	3121.4	147.0
		≥ 35 yr	5.0	0.051	0.671	882.1	12.4	2684.9	37.8	3427.4	146.9
		≥ 30 yr	5.0	0.049	0.674	902.2	12.2	2764.8	37.3	3552.0	146.9
	HC	Whole	5.0	0.021	0.883	6834.3	7.7	58218.5	65.4	15277.9	146.1
		≥ 80 yr	5.0	0.238	0.000	446.3	42.5	446.3	42.5	1565.3	149.1
		≥ 75 yr	5.0	0.129	0.500	941.8	24.4	1883.7	48.7	2843.9	147.1
		≥ 70 yr	5.0	0.101	0.538	693.8	20.0	1503.3	43.3	2356.2	146.9
		≥ 65 yr	5.0	0.070	0.630	1046.6	15.1	2832.1	40.9	3755.2	146.6
		≥ 60 yr	5.0	0.049	0.744	1677.6	12.0	6542.7	46.7	5254.5	146.4
		≥ 55 yr	5.0	0.040	0.794	2611.7	10.5	12685.3	51.1	7474.5	146.3
		≥ 50 yr	5.0	0.033	0.824	3519.3	9.5	19989.5	53.8	9558.2	146.2
		≥ 45 yr	5.0	0.026	0.848	4577.8	8.5	30179.8	55.7	12010.0	146.2
		≥ 40 yr	5.0	0.023	0.871	5726.3	8.0	44326.1	61.8	13537.7	146.2
		≥ 35 yr	5.0	0.021	0.879	6443.2	7.8	53455.1	64.6	14572.3	146.1
		≥ 30 yr	5.0	0.021	0.881	6737.6	7.7	56396.5	64.7	15225.1	146.1
	AC	Whole	5.0	0.126	0.631	515.4	24.2	1397.6	65.5	1170.9	148.8
		≥ 80 yr	5.0	0.260	0.557	378.1	45.8	853.5	103.4	559.6	153.0
		≥ 75 yr	5.0	0.260	0.640	449.7	45.2	1249.2	125.5	547.0	152.7
		≥ 70 yr	5.0	0.256	0.634	439.0	44.4	1200.5	121.3	551.5	152.4
		≥ 65 yr	5.0	0.240	0.634	433.8	42.0	1186.4	114.8	574.1	152.0
		≥ 60 yr	5.0	0.219	0.624	436.5	38.9	1161.3	103.4	639.4	151.5
		≥ 55 yr	5.0	0.197	0.621	445.2	35.4	1173.3	93.4	719.0	150.9
		≥ 50 yr	5.0	0.171	0.616	471.6	31.2	1229.4	81.5	868.1	149.9
		≥ 45 yr	5.0	0.146	0.626	493.5	27.4	1319.3	73.2	1006.5	149.3
		≥ 40 yr	5.0	0.134	0.628	508.3	25.5	1367.6	68.6	1103.8	149.0
		≥ 35 yr	5.0	0.129	0.629	513.2	24.6	1383.2	66.3	1151.7	148.9
		≥ 30 yr	5.0	0.126	0.631	516.1	24.2	1400.2	65.7	1168.9	148.8
CA19-9	Whole	Whole	37.0	0.032	0.789	1405.2	12.2	6656.1	57.7	3574.3	146.9
		≥ 80 yr	37.0	0.168	0.741	494.9	33.5	1908.7	129.3	584.4	152.7
		≥ 75 yr	37.0	0.164	0.735	505.6	32.7	1906.7	123.2	623.2	151.8
		≥ 70 yr	37.0	0.137	0.761	546.5	28.5	2288.5	119.3	691.5	150.9
		≥ 65 yr	37.0	0.115	0.762	589.9	25.0	2474.1	104.7	844.6	149.9
		≥ 60 yr	37.0	0.090	0.754	633.2	21.2	2568.7	85.8	1099.1	149.0
		≥ 55 yr	37.0	0.070	0.764	736.3	18.1	3114.0	76.7	1424.3	148.3
		≥ 50 yr	37.0	0.054	0.774	913.9	15.5	4035.0	68.4	1972.8	147.6
		≥ 45 yr	37.0	0.042	0.782	1108.4	13.6	5075.1	62.4	2614.6	147.2
		≥ 40 yr	37.0	0.036	0.785	1254.6	12.7	5833.6	59.1	3121.4	147.0
		≥ 35 yr	37.0	0.033	0.789	1359.0	12.3	6434.6	58.2	3427.4	146.9
		≥ 30 yr	37.0	0.032	0.789	1398.6	12.2	6634.7	57.8	3552.0	146.9
	HC	Whole	37.0	0.014	0.917	11789.9	9.3	142719.5	112.8	15277.9	146.1
		≥ 80 yr	37.0	0.143	0.500	622.7	29.7	1245.5	59.3	1565.3	149.1
		≥ 75 yr	37.0	0.078	0.833	2187.1	18.9	13122.9	113.1	2843.9	147.1
		≥ 70 yr	37.0	0.048	0.808	1207.9	14.5	6281.3	75.3	2356.2	146.9
		≥ 65 yr	37.0	0.043	0.783	1621.1	13.8	7457.1	63.3	3755.2	146.6
		≥ 60 yr	37.0	0.032	0.808	2252.2	12.1	11711.6	62.8	5254.5	146.4
		≥ 55 yr	37.0	0.026	0.853	3855.6	11.1	26218.2	75.5	7474.5	146.3
		≥ 50 yr	37.0	0.020	0.873	5259.2	10.2	41488.9	80.5	9558.2	146.2
		≥ 45 yr	37.0	0.016	0.899	7832.3	9.6	77452.6	95.3	12010.0	146.2
		≥ 40 yr	37.0	0.014	0.909	9540.9	9.4	104950.4	103.0	13537.7	146.2
		≥ 35 yr	37.0	0.014	0.915	10937.8	9.3	128950.9	109.7	14572.3	146.1
		≥ 30 yr	37.0	0.014	0.916	11530.0	9.3	137146.2	110.7	15225.1	146.1
	AC	Whole	37.0	0.082	0.763	663.4	20.0	2793.3	84.3	1170.9	148.8
		≥ 80 yr	37.0	0.170	0.747	488.5	33.8	1929.4	133.5	559.6	153.0
		≥ 75 yr	37.0	0.180	0.731	469.9	35.2	1749.5	131.1	547.0	152.7
		≥ 70 yr	37.0	0.171	0.757	502.4	33.7	2069.9	138.9	551.5	152.4
		≥ 65 yr	37.0	0.159	0.760	503.3	32.0	2093.5	133.2	574.1	152.0
		≥ 60 yr	37.0	0.144	0.748	496.7	29.7	1967.4	117.7	639.4	151.5
		≥ 55 yr	37.0	0.126	0.753	519.6	26.9	2105.0	109.0	719.0	150.9
		≥ 50 yr	37.0	0.109	0.759	581.1	24.2	2411.0	100.4	868.1	149.9
		≥ 45 yr	37.0	0.095	0.762	620.3	21.9	2601.4	92.0	1006.5	149.3
		≥ 40 yr	37.0	0.087	0.761	644.3	20.8	2694.8	87.0	1103.8	149.0
		≥ 35 yr	37.0	0.083	0.763	659.0	20.2	2780.6	85.2	1151.7	148.9
		≥ 30 yr	37.0	0.082	0.763	663.9	20.0	2805.1	84.5	1168.9	148.8
CA72-4	Whole	Whole	6.0	0.126	0.756	2584.5	25.9	10605.1	106.2	3574.3	146.9
		≥ 80 yr	6.0	0.194	0.790	676.1	37.1	3221.6	176.7	584.4	152.7
		≥ 75 yr	6.0	0.190	0.762	627.4	36.3	2641.0	152.8	623.2	151.8
		≥ 70 yr	6.0	0.180	0.755	651.5	34.8	2661.4	142.2	691.5	150.9
		≥ 65 yr	6.0	0.173	0.749	749.3	33.4	2980.7	133.0	844.6	149.9
		≥ 60 yr	6.0	0.166	0.745	933.2	32.3	3653.5	126.5	1099.1	149.0
		≥ 55 yr	6.0	0.158	0.746	1167.6	30.9	4599.8	121.6	1424.3	148.3
		≥ 50 yr	6.0	0.147	0.749	1552.7	29.1	6194.2	116.2	1972.8	147.6
		≥ 45 yr	6.0	0.139	0.753	2003.3	27.9	8106.4	112.8	2614.6	147.2
		≥ 40 yr	6.0	0.132	0.752	2293.2	26.7	9259.2	108.0	3121.4	147.0
		≥ 35 yr	6.0	0.128	0.755	2488.4	26.2	10145.7	106.7	3427.4	146.9
		≥ 30 yr	6.0	0.127	0.755	2565.2	25.9	10489.2	106.1	3552.0	146.9
	HC	Whole	6.0	0.108	0.870	18401.4	23.0	141077.7	176.0	15277.9	146.1
		≥ 80 yr	6.0	0.333	0.500	1206.6	57.5	2413.3	114.9	1565.3	149.1
		≥ 75 yr	6.0	0.190	0.667	2042.4	35.2	6127.2	105.6	2843.9	147.1
		≥ 70 yr	6.0	0.144	0.808	2375.7	28.5	12353.8	148.1	2356.2	146.9
		≥ 65 yr	6.0	0.126	0.848	4345.5	25.8	28556.3	169.7	3755.2	146.6
		≥ 60 yr	6.0	0.118	0.821	4898.1	24.5	27289.4	136.5	5254.5	146.4
		≥ 55 yr	6.0	0.119	0.843	8033.4	24.7	51212.7	157.2	7474.5	146.3
		≥ 50 yr	6.0	0.118	0.866	11985.7	24.5	89577.1	183.4	9558.2	146.2
		≥ 45 yr	6.0	0.116	0.854	13653.0	24.3	93470.7	166.2	12010.0	146.2
		≥ 40 yr	6.0	0.111	0.861	15690.0	23.5	113076.5	169.4	13537.7	146.2
		≥ 35 yr	6.0	0.109	0.866	17224.4	23.1	128608.7	172.7	14572.3	146.1
		≥ 30 yr	6.0	0.108	0.867	18051.9	23.0	135991.3	173.3	15225.1	146.1
	AC	Whole	6.0	0.177	0.733	997.5	33.8	3736.5	126.8	1170.9	148.8
		≥ 80 yr	6.0	0.183	0.797	643.0	35.6	3174.8	175.8	559.6	153.0
		≥ 75 yr	6.0	0.190	0.766	558.4	36.5	2383.4	155.8	547.0	152.7
		≥ 70 yr	6.0	0.194	0.751	539.5	37.2	2165.0	149.1	551.5	152.4
		≥ 65 yr	6.0	0.202	0.739	554.2	38.2	2126.5	146.7	574.1	152.0
		≥ 60 yr	6.0	0.212	0.736	634.8	39.7	2405.9	150.4	639.4	151.5
		≥ 55 yr	6.0	0.206	0.735	694.1	38.6	2617.8	145.6	719.0	150.9
		≥ 50 yr	6.0	0.194	0.732	793.2	36.7	2963.2	137.0	868.1	149.9
		≥ 45 yr	6.0	0.186	0.736	901.9	35.4	3410.7	133.8	1006.5	149.3
		≥ 40 yr	6.0	0.182	0.731	953.6	34.6	3547.9	128.7	1103.8	149.0
		≥ 35 yr	6.0	0.179	0.732	984.8	34.1	3674.4	127.3	1151.7	148.9
		≥ 30 yr	6.0	0.177	0.733	995.6	33.9	3723.6	126.8	1168.9	148.8

The economic indicators were total cost, cost per capita and their cost-effectiveness ratios. The units of carcinoembryonic antigen, carbohydrate antigen 19-9, and carbohydrate antigen 72-4 are μg/L, kU/L, and kU/L, respectively. C/E: Cost-effectiveness ratio; CEA: Carcinoembryonic antigen; CA19-9: Carbohydrate antigen 19-9; CA72-4: Carbohydrate antigen 72-4; HC: Health checkup; AC: Active consultation.