Prostaglandin F2α synthase promotes oxaliplatin resistance in colorectal cancer through prostaglandin F2α-dependent and F2α-independent mechanism

Figure 5 Prostaglandin F_2α synthase knockdown improves oxaliplatin efficiency in vivo. A: Morphologies of collected tumors in subcutaneous HCT8-OxR xenografts in nude mice; B: Curves of tumor growth in each group; C: Tumor weights were measured after collection; D: Hematoxylin-eosin (upper panel; magnification, × 200) and immunohistochemical staining for proliferating cell nuclear antigen (bottom panel; magnification, × 200) using xenograft tumor samples from each group. ^aP < 0.05, ^bP < 0.01. PCNA: Proliferating cell nuclear antigen; PGFS: Prostaglandin F_2α synthase; HE: Hematoxylin and eosin; Oxa: Oxaliplatin.